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Levodropropizine

Levodropropizine structure

CAS No:
99291-25-5
Formula:
C13H20N2O2
Chemical Name:
Levodropropizine
Synonyms:
1,2-Propanediol,3-(4-phenyl-1-piperazinyl)-,(2S)-;1,2-Propanediol,3-(4-phenyl-1-piperazinyl)-,(S)-;(2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol;(-)-Dropropizine;Levodropropizine;l-Dropropizine;(S)-(-)-Dropropizine;LVDP;Levotuss;(2S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol;(S)-Dropropizine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.

Levodropropizine is a member of the class of N-arylpiperazines that is N-phenylpiperazine in which the amino hydrogen is replaced by a 2,3-dihydroxypropyl group (the S-enantiomer). A peripherally acting antitussive drug that is used as an alternative to opioids. It has a role as an antitussive. It is a N-alkylpiperazine, a N-arylpiperazine and a secondary alcohol.|Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).

Levodropropizine Basic Attributes

Molecular Weight：

236.31

Exact Mass：

236.31

EC Number：

1592732-453-0

UNII：

3O31P6T4G3

DSSTox ID：

DTXSID8023210

ATC Code：

R05DB27|R - Respiratory system

HScode：

2933599090

Characteristics

PSA：

46.9

XLogP3：

0.6

Density：

1.2±0.1 g/cm3

Melting Point：

102-104 °C

Flash Point：

220.9±24.3 °C

Refractive Index：

1.577

Storage Conditions：

Refrigerator

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 7 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

MeSH Entry Terms：

DF 526

Levodropropizine Use and Manufacturing

Cough Suppressant

Computed Properties

Molecular Weight:236.31
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:236.152477885
Monoisotopic Mass:236.152477885
Topological Polar Surface Area:46.9
Heavy Atom Count:17
Complexity:212
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Levodropropizine Dispersible Tablets
Ingredients	The main ingredient of this product is levodropropizine.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	60mg
Manufacturer	Harbin Pharmaceutical Group Pharmaceutical Factory No.6

Levodropropizine Capsules
Ingredients	Levodropropizine. Chemical name: S (-) -3- (4-phenyl-1-piperazinyl) -1,2-propanediol Molecular weight: C13H20N2O2
Indication	1. According to pharmacological studies on experimental animals, this product is rapidly absorbed by the nervous system. 2. It also affects the hypoglycemic effect of insulin and digestive system drugs. 3. For particularly sensitive patients, caution should be exercised when taking inhibitory drugs at the same time. 4. Clinical studies have not found any adverse effects on the simultaneous use of other drugs for the treatment of bronchopneumonia.
Specifications	60 mg
Manufacturer	Hunan Jiudian Pharmaceutical Co., Ltd.

Levodropropizine lozenges
Ingredients	The active ingredient of this product is levoproprazine. Chemical name: (-)-3-(4-phenyl-1-piperazinyl)-1,2-propanediol Chemical structure: Molecular formula: C13H20N2O2 Molecular weight: 236.32
Indication	1. According to pharmacological studies on experimental animals, this product is rapidly absorbed by the nervous system. 2. It also affects the hypoglycemic effect of insulin and digestive system drugs. 3. For particularly sensitive patients, caution should be exercised when taking inhibitory drugs at the same time. 4. Clinical studies have not found any adverse effects on the simultaneous use of other drugs for the treatment of bronchopneumonia.
Specifications	60mg
Manufacturer	Hunan Jiudian Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Kunming Yuanrui Pharmaceutical Co., Ltd.

China
Active
GUIZHOU-EAKAN Pharmaceutical Co., Ltd.

China
Active
Hunan Jiudian HONGYANG Pharmaceutical Co., Ltd.

China
Active

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