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Molsidomine

Molsidomine structure

CAS No:
25717-80-0
Formula:
C9H14N4O4
Chemical Name:
Molsidomine
Synonyms:
1,2,3-Oxadiazolium,5-[(ethoxycarbonyl)amino]-3-(4-morpholinyl)-,inner salt;Sydnone imine,N-carboxy-3-morpholino-,ethyl ester;Sydnone imine,N-(ethoxycarbonyl)-3-(4-morpholinyl)-;N-Ethoxycarbonyl-3-morpholinosydnonimine;N-(Ethoxycarbonyl)-3-morpholinosydnone imine;Molsidomine;Morial;Corvaton;SIN 10;SIN 10 (pharmaceutical);Sydnopharm;Corraton;Morsydomine;Corvasal;Molsidolat;CAS 276;Motazomin;Coruno;Molsicor;625821-16-1;2125492-39-7
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Molsidomine is an orally active, long acting vasodilating drug, metabolized in the liver to the active metabolite linsidomine, which is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

Molsidomine is a member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure. It has a role as a vasodilator agent, an antioxidant, a nitric oxide donor, an apoptosis inhibitor and a cardioprotective agent. It is a member of morpholines, an oxadiazole, an ethyl ester and a zwitterion.|A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.

Molsidomine Basic Attributes

Molecular Weight：

242.23

Exact Mass：

242.101501

EC Number：

247-207-4

DSSTox ID：

DTXSID0045171

ATC Code：

C01DX12

HScode：

2934999090

Characteristics

PSA：

87 Å²

XLogP3：

-1.61

Density：

1.3186 (rough estimate)

Melting Point：

140.5 °C

Boiling Point：

266°C

Water Solubility：

0.00465 to 1.74

Storage Conditions：

2-8°C

Toxicity：

LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

WU7677400

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 45 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)|A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81) (See all compounds classified as Nitric Oxide Donors.)

MeSH Entry Terms：

Corpea

Molsidomine Use and Manufacturing

Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.

Computed Properties

Molecular Weight:242.23
XLogP3:2.2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:242.10150494
Monoisotopic Mass:242.10150494
Topological Polar Surface Area:87
Heavy Atom Count:17
Complexity:270
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Molsomal tablets
Specifications	2mg
Manufacturer	China Resources Double-Crane Pharmaceutical Co., Ltd.

Molsomal tablets
Specifications	2mg
Manufacturer	Shanghai Zhonghua Pharmaceutical Co., Ltd.

Molsidomide aerosol
Ingredients	This product is an ethanol solution of molsidomine, with chlorofluorocarbon as the propellant, and is stored in a pressure-resistant container with a quantitative valve system. Each bottle should contain 120-167 mg of molsidomine (C9H14N4O4), and the concentration of molsidomine is 0.8%-1.3% (w/w).
Indication	Not yet clear.
Specifications	1%, each bottle weighs 14 grams, containing 140 mg of molsidomide
Manufacturer	Heilongjiang Fulekang Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

China Resources Double-Crane Pharmaceutical Co., Ltd.

China
Active
Jiangsu Baoshenglongcheng Pharmaceutical Co., Ltd.

China
Active
Shanghai New Hualian Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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