Pramipexole dihydrochloride
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Pramipexole dihydrochloride
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CAS No:
104632-25-9
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Formula:
C10H17N3S.2ClH
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Chemical Name:
Pramipexole dihydrochloride
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Synonyms:
2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,hydrochloride (1:2),(6S)-;2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,dihydrochloride,(S)-;2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,dihydrochloride,(6S)-;Pramipexole dihydrochloride;SND 19;Pramipexole hydrochloride
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CAS No:
Description
White Crystalline PowderChEBI: A hydrochloride that is the anhydrous dihydrochloride salt of pramipexole.Mirapex, an non ergot derivative, was launched in the US for treatment of Parkinson's disease. It had an adverse events profile similar to other dopamine agonists and in advanced patients reduced the mean on-off hr/day from 6 to 4. It was safe but not efficacious in all patients.Pramipexole dihydrochloride,(S)-2-amino-6-propylamino-dihydrochloride(Mirapex), is a white to off-white powder
Pramipexole hydrochloride anhydrous is a hydrochloride that is the anhydrous dihydrochloride salt of pramipexole. It has a role as a dopamine agonist and an antiparkinson drug. It contains a pramipexole(2+).|A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.
Pramipexole dihydrochloride Basic Attributes
284.25
283.067688
1806241-263-5
4R2HD0M28N
DTXSID90146623
2934999090
Characteristics
79.2
4.15830
white crystalline powder
296-298 °C
378ºC at 760 mmHg
182.4ºC
H2O: >20mg/mL
Desiccate at RT
6.49E-06mmHg at 25°C
Safety Information
NONH for all modes of transport
3
P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P321, P330, P333+P313, P363, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P321, P330, P333+P313, P363, and P501|Aggregated GHS information provided by 55 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)|Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)|Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)
2 Amino 6 propylaminotetrahydrobenzothiazole
Pramipexole dihydrochloride Use and Manufacturing
A dopamine-D2-receptor agonist. Antiparkinsonian
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:284.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:283.0676742
Monoisotopic Mass:283.0676742
Topological Polar Surface Area:79.2
Heavy Atom Count:16
Complexity:188
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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