Barnidipine hydrochloride
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Barnidipine hydrochloride
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CAS No:
104757-53-1
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Formula:
C27H29N3O6.ClH
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Chemical Name:
Barnidipine hydrochloride
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Synonyms:
3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-methyl 5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester,hydrochloride (1:1),(4S)-;3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,methyl 1-(phenylmethyl)-3-pyrrolidinyl ester,monohydrochloride,[S-(R*,R*)]-;3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,methyl (3S)-1-(phenylmethyl)-3-pyrrolidinyl ester,monohydrochloride,(4S)-;YM 09730-5;Barnidipine hydrochloride;112283-30-4
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Pale Yellow SolidBarnidipine hydrochloride is a vasodilating dihydropyridine calcium antagonist useful in the treatment of hypertension. In experimental animals, its hypotensive effect was more potent and longer acting than nicardipine, nifedipine and nitrendipine.
Barnidipine hydrochloride is a dihydropyridine.
Characteristics
113.69000
5.41220
226-228 °C
614.5ºC at 760 mmHg
325.4ºC
Refrigerator
4.94E-15mmHg at 25°C
LD50 orally in male, female rats: 105, 113 mg/kg (Satoh)
D20 +116.4° (c = 1 in methanol)
Safety Information
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)
1-benzyl-3-pyrrolidinyl methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Barnidipine hydrochloride Use and Manufacturing
1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. A potential candidate in the treatment of patients with renal parenchymal hypertension.
Computed Properties
Molecular Weight:528.0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:527.1823134
Monoisotopic Mass:527.1823134
Topological Polar Surface Area:114
Heavy Atom Count:37
Complexity:917
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
No specific description provided
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