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Pramiracetam

Pramiracetam structure

CAS No:
68497-62-1
Formula:
C14H27N3O2
Chemical Name:
Pramiracetam
Synonyms:
1-Pyrrolidineacetamide,N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo-;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide;Amacetam;Pramiracetam;Vinpotropil
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Pramiracetam is a nootropic drug derived from piracetam, and is more potent. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries. IC50 Value: Target: in vitro: Pramiracetam sulfate did not exhibit any affinity in vitro for dopaminergic , GABAergic, serotoninergic, adrenergic, muscarinic, adenosine (IC50 > 10 uM), and benzodiazepine receptors (IC50 > 1 uM) binding sites [1].in vivo: In a double-blind, randomized design, two groups of six subjects e

Pramiracetam is an organonitrogen compound and an organooxygen compound. It derives from an alpha-amino acid.|Pramiracetam has been previously approved in some eastern European countries under the brand names Pramistar, Neupramir, and Remen. It was also previously approved in the United States with orphan drug designation. Pramiracetam has been studied for the use in Alzheimer's disease and as an adjunct treatment to restore cognitive functioning post-electroconvulsive therapy in severe depression.

Pramiracetam Basic Attributes

Molecular Weight：

269.38

Exact Mass：

269.38

EC Number：

1308068-626-2

UNII：

4449F8I3LE

DSSTox ID：

DTXSID60218604

ATC Code：

N - Nervous system

HScode：

2933790090

Characteristics

PSA：

52.6

XLogP3：

0.8

Appearance：

white crystalline powder

Density：

1.0±0.1 g/cm3

Melting Point：

47-48°

Boiling Point：

162-164 °C @ Press: 0.15 Torr

Flash Point：

232.6±24.6 °C

Refractive Index：

1.495

Water Solubility：

H2O: soluble 10mg/mL, clear

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

UV6264081

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

N-(2-(bis(1-methylethyl)amino)ethyl)-2-oxo-1-pyrrolidineacetamide

Pramiracetam Use and Manufacturing

Pramiracetam is a more potent nootropic drug derived from piracetam. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries. Pramiracetam was also effective in the treatment of cognitive disorders of cerebrovascular a

Computed Properties

Molecular Weight:269.38
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:269.21032711
Monoisotopic Mass:269.21032711
Topological Polar Surface Area:52.6
Heavy Atom Count:19
Complexity:308
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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