2,6-Diamino-4-pyrimidinol

Solid

Solid

General procedure: In a 10 mL round-bottomed flask, a mixture of aldehyde (1 mmol), uracil derivatives (1 mmol), dimedone (1 mmol, 0.14 g) and MIL-100(Cr)/NHEtN(CH2PO3H2)2 (0.01 g) were stirred at 100 C in DMF(5 ml) as solvent. After completion of the reaction as monitored by TLC, the reaction mixture was cooled to room temperature. Then, the catalystwas separated from the solution of reaction mixture by centrifugation(1000 rpm). Then, H2O (5 ml) was added to reaction mixtureto give the solid sediment. The prepared solid was collected by simplefiltration. The crude product was purified by recrystallization fromEtOAc (Scheme 3). The pure products were identified by FT-IR, 1H, 13CNMR and mass spectra.General procedure: In a 10 mL round-bottomed flask, a mixture of aldehyde (1 mmol), uracil derivatives (1 mmol), dimedone (1 mmol, 0.14 g) and MIL-100(Cr)/NHEtN(CH2PO3H2)2 (0.01 g) were stirred at 100 C in DMF(5 ml) as solvent. After completion of the reaction as monitored by TLC, the reaction mixture was cooled to room temperature. Then, the catalystwas separated from the solution of reaction mixture by centrifugation(1000 rpm). Then, H2O (5 ml) was added to reaction mixtureto give the solid sediment. The prepared solid was collected by simplefiltration. The crude product was purified by recrystallization fromEtOAc (Scheme 3). The pure products were identified by FT-IR, 1H, 13CNMR and mass spectra.

Molecular Weight:126.12
XLogP3:-1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Exact Mass:126.05416083
Monoisotopic Mass:126.05416083
Topological Polar Surface Area:93.5
Heavy Atom Count:9
Complexity:205
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes