2-BROMO-5-METHOXYPYRIDINE
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2-BROMO-5-METHOXYPYRIDINE
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CAS No:
105170-27-2
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Formula:
C6H6BrNO
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Chemical Name:
2-BROMO-5-METHOXYPYRIDINE
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Synonyms:
2-Bromo-5-methoxypyridine;PYRIDINE, 2-BROMO-5-METHOXY-;ABBYPHARMA AP-17-5961;2-bromo-5-methoxy-pyridine;PubChem15210;ACMC-1C4T9;KSC494G3B;SCHEMBL502881;CTK3J4330;DTXSID40456885
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CAS No:
Characteristics
22.1
1.8
1.530±0.06 g/cm3(Predicted)
113 °C(Press: 59 Torr)
99.4±21.8 °C
1.543
0.0577mmHg at 25°C
Safety Information
Xi
Irritant
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-BROMO-5-METHOXYPYRIDINE Use and Manufacturing
2-Bromo-5-hydroxypyridine (5 mmol) is dissolved in DMF (10 ml) and NaH (1.4 eq., 60percent suspension in liquid paraffin) is added. After 30 min iodomethane (2 eq.) is added and the reaction solution is stirred 3 days. The reaction solution is pored into water and extracted with methyl-tert-15 butyl ether. The combined organic layers are dried over MgSO(a) (a) 2-Bromo-5-hydroxypyridine (5 mmol) is dissolved in DMF (10 ml) and NaH (1.4 eq., 60% suspension in liquid paraffin) is added. After 30 min iodomethane (2 eq.) is added and the reaction solution is stirred 3 days. The reaction solution is pored into water and extracted with methyl-tert-15 butyl ether. The combined organic layers are dried over MgSO4 and the solvent is removed in vacuo. 2-Bromo-5-methoxy-pyridine is obtained as yellow oil in a yield of 79 %; HPLC (method C): 1.49 min; LC-MS (method A): 1.16 min, 187.95 (M+H+).
Computed Properties
Molecular Weight:188.02
XLogP3:1.8
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:186.96328
Monoisotopic Mass:186.96328
Topological Polar Surface Area:22.1
Heavy Atom Count:9
Complexity:89.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-BROMO-5-METHOXYPYRIDINE
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CN
2 YRS
Business licensedTrader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic AcidInquiryCAS No.: 105170-27-2Grade: Pharmaceutical GradeContent: 99% -
InquiryCAS No.: 105170-27-2Grade: Industrial GradeContent: 99%
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CN
4 YRS
Business licensedTrader Supplier of API OLED Organic intermediate
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