2-Fluoro-3-pyridinemethanol

Sodium borohydride 1.0 g (26 mmol) was added to an ethanol (14 mL) solution of 2-fluoronicotinaldehyde 1.6 mL (16 mmol), and the mixture was stirred at room temperature for 1 hour. Weigh 10g (70.87mmol)2-fluoro nicotinic acid solubleIn 330mL anhydrous tetrahydrofuran, Stir in an ice bath and slowly add 4.3 g (113.07 mmol) of LiA1H4 in small portions.Generate a lot of air bubbles, with the increase in the amount of LiA1H4 added, The reaction solution was cloudy with white turbidity and yellow.After the addition, the reaction is continued for 20 minutes. The TLC monitors and the reaction is complete. Slowly add 10.6 mL of water to quench the reaction.A large amount of bubbles and solids were generated, and the mixture was suction-filtered. The solvent was evaporated under reduced pressure to give 7.78 g of a yellow liquid, which was used.Weigh 10 g (70.87 mmol) of 2-fluoronicotinic acid in 330 mL of anhydrous tetrahydrofuran and stir overnight in an ice bath. A small portion is slowly added with 4.3 g (113.07 mmol) of LiA1H4 to generate a large amount of bubbles. As the amount of LiAlH4 added increases, The reaction solution was yellow and turbid with white turbidity. After the addition, the reaction was continued for 2omin. TLC monitored the reaction. The reaction was completely quenched by slowly adding 10.6 mL of water to generate a large amount of bubbles and solids. The filtrate was filtered off and the solvent was evaporated under reduced pressure to give a yellow liquid. 7.78g, ready for use.At 0C, 55% sodium hydride 0.70 g (16 mmol) was added in portions to a THF (20 mL) solution of

Molecular Weight:127.12
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:127.043341977
Monoisotopic Mass:127.043341977
Topological Polar Surface Area:33.1
Heavy Atom Count:9
Complexity:89.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes