2-Fluoropyridine-4-carboxaldehyde
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2-Fluoropyridine-4-carboxaldehyde
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CAS No:
131747-69-8
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Formula:
C6H4FNO
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Chemical Name:
2-Fluoropyridine-4-carboxaldehyde
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Synonyms:
4-Pyridinecarboxaldehyde,2-fluoro-;2-Fluoro-4-pyridinecarboxaldehyde;2-Fluoropyridine-4-carboxaldehyde;2-Fluoropyridine-4-carbaldehyde;2-Fluoroisonicotinaldehyde;2093385-80-7
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CAS No:
Safety Information
IRRITANT, KEEP COLD
3
36/37/38-36/38-22
26-36/37/39
Xi,Xn
P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Fluoropyridine-4-carboxaldehyde Use and Manufacturing
To a solution of Compound 22-2 (300 mg, 1.51 mmol) in dichloromethane (2 mL), Compound VI (23.8 g, 0.1 mol) was added to a 500 mL three-necked flask, followed by tetrahydrofuran (100 mL).Turn on the agitation, under nitrogen protection, Lithium tetramethylpiperidine (LTMP) (44 mL, 0.11 mol) was added dropwise at -40 ° C, and the addition was completed.The mixture was further stirred at low temperature for 0.5 hour, and then a solution of 2-fluoro-pyridinecarboxaldehyde (12.5 g, 0.1 mol) in tetrahydrofuran was added dropwise.After the drop, continue to react at -40 ° C for 1 hour, TLC point plate monitoring, After the material point disappears, a saturated ammonium chloride solution is added dropwise below zero.Add ethyl acetate, extract, separate the organic layer, and dry over anhydrous sodium sulfate.Filtered, and the filtrate was concentrated under reduced pressure.Obtained a yellow solid compound V-2, 31.9 g, The yield was 88percent.
Computed Properties
Molecular Weight:125.10
XLogP3:0.7
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:125.027691913
Monoisotopic Mass:125.027691913
Topological Polar Surface Area:30
Heavy Atom Count:9
Complexity:107
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Fluoropyridine-4-carboxaldehyde
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Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 131747-69-8Grade: Industrial GradeContent: 95%
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2-Fluoropyridine-4-carboxaldehyde
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