3,4-Pyridinediamine,5-methyl-(9CI)

Amixture of 4-amino-3-methyl-5-nitropyridine (1. 198 g), iron powder (1.748 g), ethanol (52 mL) and hydrochloric acid (13 mL) was heated to reflux for 3 hours. After cooling to room temperature the ethanol was distilled off and the resulting suspension was diluted with water to 50 mL and the pH was adjusted to 13 by addition of 2N NaOH. Extraction with ethyl acetate (3 x 70 mL), drying of the combined organic phases of anhydrous sodium sulphate and evaporation of the solvent afforded 0.579 g (60percent) of 3, 4-diamino-5-metl1ylpyridine.Representative compounds of the present invention are: ... 6-bromo-4-methyl-2, 3-pyridinediamine; 5-bromo-6-methyl-2, 3-pyridinediamine; 6-methoxy-3, 4-pyridinediamine; 2-methoxy-3, 4-pyridinediamine; 5-methyl-3, 4-pyridinediamine; 5-methoxy-3, 4-pyridinediamine; 5-bromo-3, 4-pyridinediamine; 2, 3, 4-pyridinetriamine; ...1a 3-Methyl-4, 5-diaminopyridine 3-Methyl-4, 5-diaminopyridine was prepared according to the methods by B. Brekiesz-Lewandowska et al. [Rocz. Chem., 41, 1887 (1967); C.A. 69, 2911w (1968)]. (413 mg, 3.35 mmol)Mixed with 20 ml of dimethyl oxalate, Warm to reflux and stir for 3-4 hours.After the reaction solution was cooled, the resulting solid was filtered off.The solid was dispersed in 15 ml of N, N-dimethylformamide.Add 1 g of activated carbon, raise the temperature to reflux, and filter it hot after 1 hour.Add 1 ml of water to the filtrate.Allow to stand for 1 hour, The precipitated white solid is filtered, Washed with water, washed with 95% ethanol, Ethyl acetate wash to give 8-methyl-6-azaquinoxaline-2, 3-dione white solid(434 mg, yield 73.1%).7-Methyl-1, 3-dihydro-2H-imidazo[4, 5-c]pyridine-2-thione (Compound 8): To a solution of To a solution of Aquo composite of 7-methyl-1H-[1, 2, 3]triazolo[4, 5-c]pyridinium nitrate was obtained from

Molecular Weight:123.16
XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:123.079647300
Monoisotopic Mass:123.079647300
Topological Polar Surface Area:64.9
Heavy Atom Count:9
Complexity:94.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes