2-BROMO-6-FLUOROPYRIDINE
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2-BROMO-6-FLUOROPYRIDINE
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CAS No:
144100-07-2
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Formula:
C5H3BrFN
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Chemical Name:
2-BROMO-6-FLUOROPYRIDINE
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Synonyms:
2-bromo-6-fluoropyridine;6-bromo-2-fluoropyridine;937379-49-2;2-Fluoro-6-bromopyridine;pyridine, 2-bromo-6-fluoro-;2-Bromo-6-fluoro-pyridine;ABBYPHARMA AP-17-5098;MFCD03095258;Platinum(1+), (2-bromo-5-fluoropyridine-kappaN)(9-hydroxy-6-methylpyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(1H,6H)-dionato-kappaN1,kappaN12)(6-methyl-3-pyridinol-kappaN1)-, (SP-4-2)-, hexafluorophosphate(1-);2?bromo?6?fluoropyridine
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CAS No:
Characteristics
12.9
1.8
1.707±0.06 g/cm3(Predicted)
30-32°C
162-164°C
74.9±21.8 °C
1.532
Room temperature.
Safety Information
6.1
36/37/38-20/21/22-10-41-37/38-22
26-36/37/39-36-16-39
Xi,Xn,F
Irritant
P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501
H301
|Danger|H301 (57.14%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 7 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-BROMO-6-FLUOROPYRIDINE Use and Manufacturing
Into a 50 mL flask equipped with a reflux condenser, 500 mg of the fluorinating agent (1) synthesized in Example 1, 236 mg of 2, 6-dibromopyridine and 2 g of acetonitrile were charged and the resulting mixture was stirred for 3 hours at 80°C. After cooling to room temperature, 5 g of ethyl acetate and 5 g of water were added thereto and stirred. The mixture was separated to two layers by standing. The upper layer was analyzed by gas chromatography (internal standard method) to find that the main product was 2-fluoro-6-bromopyridine. Yield: 78percent (based on 2, 6-dibromopyridine). 2, 6-dibromopyridine was recovered in 20percent.
Computed Properties
Molecular Weight:175.99
XLogP3:1.8
Hydrogen Bond Acceptor Count:2
Exact Mass:174.94329
Monoisotopic Mass:174.94329
Topological Polar Surface Area:12.9
Heavy Atom Count:8
Complexity:78.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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