6-Chloro-N,N-dimethyl-4-pyrimidinamine

To a mixture of (S)-tert-butyl 4-((2-acetamidoethyl) (4-(5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-2-yl) butyl)amino)-2-aminobutanoate (100 mg, 223 mumol) and To a mixture of (S)-tert-butyl 2-amino-4-(((S)-2-fluoro-3-methoxypropyl) (4-(5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-2-yl) butyl)amino) butanoate (150 mg, 331 mumol) and To a mixture of tert-butyl (S)-2-amino-4-(((R)-2-methoxypropyl) (4-(5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-2-yl) butyl)amino) butanoate (152 mg, 349 mumol) and 6-chloro-N, N-dimethyl-pyrimidin-4-amine (46 mg, 291 mumol) in t-AmOH (3 mL) was added 2.0M t-BuONa in THF (291 muL, 582 mumol) then tBuXPhos-Pd-G3 (23 mg, 29 mumol) and the resulting mixture was heated to 100 C. for 2 h. The reaction mixture was cooled to rt and then concentrated in vacuo to give the title compound that was used without further purification. LCMS (ESI+): m/z=556.6 (M+H)+.

Molecular Weight:157.60
XLogP3:1.6
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:157.0406750
Monoisotopic Mass:157.0406750
Topological Polar Surface Area:29
Heavy Atom Count:10
Complexity:107
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes