 Home > Encyclopedia > Gisadenafil

Gisadenafil

Gisadenafil structure

CAS No:
334826-98-1
Formula:
C23H33N7O5S
Chemical Name:
Gisadenafil
Synonyms:
7H-Pyrazolo[4,3-d]pyrimidin-7-one,5-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-;Piperazine,1-[[6-ethoxy-5-[3-ethyl-4,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridinyl]sulfonyl]-4-ethyl-;5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one;2-(Methoxyethyl)-5-[2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl]-3-ethyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one;5-[2-Ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one;Gisadenafil;UK 369003;876921-15-2
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Gisadenafil (UK-369003) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor with an IC50 of 3.6 nM and prevents degradation of cyclic guanosine monophosphate (cGMP)[1].

Gisadenafil has been investigated for the treatment of Prostatic Hyperplasia.

Gisadenafil Basic Attributes

Molecular Weight：

519.62

Exact Mass：

519.62

UNII：

S6G4R7DI1C

Characteristics

PSA：

140

XLogP3：

2.07190

Density：

1.41

Drug Information

MeSH Entry Terms：

1-(6-ethoxy-5-(3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo(4,3-d)pyrimidin-5-yl)-3-pyridyl sulphonyl)-4-ethylpiperazine

Computed Properties

Molecular Weight:519.6
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Exact Mass:519.22638835
Monoisotopic Mass:519.22638835
Topological Polar Surface Area:140
Heavy Atom Count:36
Complexity:890
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes