2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine
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![2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/575b98d39ce64b819ad48ee4eeaa27f7.png "2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine")
2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine
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CAS No:
35265-83-9
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Formula:
C7H4Cl2N2S
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Chemical Name:
2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine
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Synonyms:
2,4-dichloro-7-methylthieno[3,2-d]pyrimidine;SCHEMBL358761;CTK4H4141;DTXSID50428053;CS-M2510;ZINC4243135;ANW-49637;RW2827;AKOS015919887;PB14528
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CAS No:
2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine Basic Attributes
219.09
217.947220
DTXSID50428053
2934999090
2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine Use and Manufacturing
A mixture of 7-methylthieno[3, 2-d]pyrirnidine-2, 4(lH, 3H)-dione (403 mg, 2.21 mmol) and phosphonyl chloride (8.0 mL, 86 mmol) was heated at 116Reference Example 17 General procedure: A total of 0.8 mL N, N-dimethylaniline was added to 3.0 g of thieno[2, 3-d]pyrimidine-2, 4-(1H, 3H)-dione 6a in 20 mL POClGeneral procedure: Synthesis of Compound 1-3 [0123] Compound 1-2 (1.34 g, 7.2 mmol) was dissolved in 20 ml phosphorus oxychloride and refluxed overnight. The reaction solution was poured into 200 ml ice water and stirred for 30 minutes. A large amount of solids was precipitated. The solids were filtered by suction, washed with water and dried, thereby obtaining the product 1-3 (1.12 g) in 69.7% yield. MS: 224.9[M+H]+.General procedure: The compound 1-1 (12.5 g, 74.3 mmol) obtained in the above step.Mix with 200 mL of phosphorus oxychloride, heat to reflux for 8 hours, and cool to room temperature.Most of the phosphorus oxychloride was distilled off under reduced pressure, and the residual liquid was slowly poured into crushed ice.Stir vigorously, precipitated as a white solid, suction filtered, washed with cold water, Drying white flocculent solid 10.2g, yield 67%.To a solution of 2, 4-dichloro-7-methylthieno[3, 2-
Computed Properties
Molecular Weight:219.09
XLogP3:3.6
Hydrogen Bond Acceptor Count:3
Exact Mass:217.9472247
Monoisotopic Mass:217.9472247
Topological Polar Surface Area:54
Heavy Atom Count:12
Complexity:181
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine
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