2,5-Diamino-4,6-dihydroxypyrimidine

20 g of guanidine hydrochloride was weighed into 500 mL of a reflux condenser, A thermometer and a dropping funnel, Add 200mL mass concentration of 30% sodium methoxide solution, Start the agitator, Stirring at 300r / min for 10min;After the completion of the stirring, 50 mL of a methanol solution having a mass concentration of 80% was added to the flask, The flask was transferred to a water bath, Heating up to 90 C, Reflux 1 ~ 3h through the dropping funnel continue to drop 50mL concentratedDegree of 3mol / L of diethyl malonate solution of methanol, dropping speed control to drop within 30min is completed, Stirring was continued for 10 min;After completion of the stirring, The mixture was allowed to cool naturally to room temperature, Into the Buchner funnel for filtration, Separating the residue into a rotary evaporator, Evaporation gave a white solid, Grinding to obtain white powder;20 g of the above-obtained white powder was weighed into a 500-mL beaker, Continue to add 200mL concentration of 70% concentrated nitric acid, Stir with a glass rod, The beaker is placed on an asbestos web, Heating it with an alcohol lamp, A thermometer was added to the beaker, and the temperature was raised to 70 C, and the heating was stopped. To the above-mentioned beaker, Into 10g sodium hydroxide powder and 2g zinc powder, stir with a glass rod evenly, then dropping through the dropping funnelInto 10mL of 30% concentration of ammonia, placed in the magnetic stirrer at 300r / min speed stirring10min; After stirring, add 30mL of 30% ammonium chloride solution to the beaker, Beaker into the ultrasonic oscillator, the ultrasonic oscillation reaction 1h, the mixture into the rotary evaporator, lWarm to 70 C, rotary evaporation of a light yellow solid, that is 2, 5 - diamino - 4, 6 - dihydroxy pyridine.A suspension of 1-phenylcyclopropanecarboxylic acid (973 mg, 6.0 mmol) in SOCl2 (5 ml) was heated under reflux for 1 h. After concentration under reduced pressure, the residue was redissolved in dioxane (5 ml) and added to a stirring solution of A suspension of 1-phenylcyclopropanecarboxylic acid (973 mg, 6.0 mmol) in SOCl2 (5 ml) was heated under reflux for 1 h. After concentration under reduced pressure, the residue was redissolved in dioxane (5 ml) and added to a stirring solution of General Procedure [0752] A suspension of 1-phenylcyclopropanecarboxylic acid (973 mg, 6.0 mmol) in SOCl2 (5 ml) was heated under reflux for 1 h. After concentration under reduced pressure, the residue was redissolved in dioxane (5 ml) and added to a stirring solution of To an ice-cooled solution of General Procedure [0737] To an ice-cooled solution of To an ice-cooled solution of To a solution of Examples 199-201 Synthesis of 2-amino-5-acylamino-4, 6-dihydroxypyrimidine analogues General Procedure [1001] To a solution of To a solution of

Molecular Weight:142.12
XLogP3:-1.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Exact Mass:142.04907545
Monoisotopic Mass:142.04907545
Topological Polar Surface Area:114
Heavy Atom Count:10
Complexity:242
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes