2-Bromo-3-chloro-5-(trifluoromethyl)pyridine
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2-Bromo-3-chloro-5-(trifluoromethyl)pyridine
structure -
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CAS No:
75806-84-7
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Formula:
C6H2BrClF3N
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Chemical Name:
2-Bromo-3-chloro-5-(trifluoromethyl)pyridine
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Synonyms:
BUTTPARK 153\33-66;2-BROMO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;2-Bromo-3-chloro-5-(trifluoromethyl)pyridine 97%;2-Bromo-3-chloro-5-(trifluoromethyl)pyridine97%;2-BROMO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRI;2-Bromo-3-chloro-5-(trifluorom;2-bromo-3-chloro-5-(triluoromethyl)pyridine;6-Bromo-5-chloro-alpha,alpha,alpha-trifluoro-3-picoline
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CAS No:
2-Bromo-3-chloro-5-(trifluoromethyl)pyridine Basic Attributes
260.44
258.901123
DTXSID40371226
2933399090
Safety Information
IRRITANT
36/37/38-36/38
26-36-37/39-37
Xi
Irritant
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 8 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Bromo-3-chloro-5-(trifluoromethyl)pyridine Use and Manufacturing
0.087 mol of 3-chloro-5-trifluoromethyl-2-hydroxypyridine (17.1 g) was added to 150 ml of phosphorus oxybromide and the reaction temperature was raised to 150 ° C and the reaction time was 6 hours.The reaction was cooled to ambient temperature and slowly added cautiously to ice-water, stirred vigorously at -200 rpm for 1 hour at -5 to 0 ° C, and the resulting mixture was extracted three times with dichloromethane.The extracted organic phases were combined, dried, filtered and dried to give the crude product.The crude product was chromatographed on a silica gel column using dichloromethane-methanol as eluent (100: 1 to 20: 1 by volume) to give 13.1 g of 2-bromo-3-chloro-5-trifluoromethylpyridine (0.05 mol) in 58percent yield.
Computed Properties
Molecular Weight:260.44
XLogP3:3.4
Hydrogen Bond Acceptor Count:4
Exact Mass:258.90112
Monoisotopic Mass:258.90112
Topological Polar Surface Area:12.9
Heavy Atom Count:12
Complexity:163
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Bromo-3-chloro-5-(trifluoromethyl)pyridine
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