3-Chloro-2,5-difluoropyridine
-
3-Chloro-2,5-difluoropyridine
structure -
-
CAS No:
851179-00-5
-
Formula:
C5H2ClF2N
-
Chemical Name:
3-Chloro-2,5-difluoropyridine
-
Synonyms:
Pyridine,3-chloro-2,5-difluoro-;3-Chloro-2,5-difluoropyridine
- Categories:
-
CAS No:
Safety Information
Ⅲ
3
2924
3,8
|Danger|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P370+P378, P403+P235, P405, and P501|Aggregated GHS information provided by 7 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
3-Chloro-2,5-difluoropyridine Use and Manufacturing
N, N-diisopropylethylamine (0.1 mL, 0.58 mmol) was added to a suspension of 3-(7- chloro-1H-indol-4-yl)-2-(2, 6-diethylphenyl)-4, 5, 6, 7-tetrahydro-2H-pyrazolo[4, 3-c]pyridine hydrochloride (45 mg, 0.10 mmol), 2-fluoro-3-chloro-5-fluoro-pyridine (1 mmol) was added to a 25 ml reaction tube.Tert-butylate hydrochloride (1 mmol), sodium methoxide (2 mmol), H2O (0.5 mL) and N, N-dimethylformamide (2.5 mL).The reaction was carried out at 140 C for a reaction time of 30 hours.After the reaction was completed, it was cooled to room temperature.Add 10 mL of ethyl acetate to quench the reaction, add 6 mL of saturated brine to wash, separate the organic phase, and then use acetic acidThe ester phase was extracted three times (each time the amount of ethyl acetate was 6 mL) and the organic phase was combined, dried over anhydrous sodium sulfate and distilled under reduced pressure.The solvent is removed, including an organic solvent and an inorganic solvent, which are separated by column chromatography to obtain the target product in a yield of87%.Sodium hydride (0.308 g, 7.69 mmol) was added to a solution of 2-((3- fluoropropyl)(methyl)amino)ethan-1-ol (1.040 g, 7.69 mmol) in THF (26.8 mL). After stirring for 10 minutes,
Computed Properties
Molecular Weight:149.52
XLogP3:2
Hydrogen Bond Acceptor Count:3
Exact Mass:148.9843831
Monoisotopic Mass:148.9843831
Topological Polar Surface Area:12.9
Heavy Atom Count:9
Complexity:101
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 3-Chloro-2,5-difluoropyridine
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives
Learn More Other Chemicals
-
(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID
51485-76-8
-
Benadryl N-oxide hydrochloride
13168-00-8
-
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE
885275-59-2
-
(2-Bromophenyl)diphenylphosphine Formula
62336-24-7
-
1-Morpholinocyclopentene Formula
936-52-7
-
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula
168892-66-8
-
3-amino-5-bromopyridine-2-carboxylic acid Structure
870997-85-6
-
2-Amino-6-methylpyridine Structure
1824-81-3
-
What is 3-Bromo-2-methylthiophene
30319-05-2
-
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER
2026-42-8