 Home > Encyclopedia > 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE

5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE

5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE structure

CAS No:
886364-86-9
Formula:
C7H5BrN2
Chemical Name:
5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE
Synonyms:
5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE;5-BroMo-2-cyano-4-Methylpyridine;5-BroMo-4-Methylpicolinonitrile;5-Bromo-2-cyano-4-methylpyridine, 5-Bromo-4-methylpicolinonitrile;5-bromo-4-methyl-2-Pyridinecarbonitrile
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Request for Quotation

5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE Basic Attributes

Molecular Weight：

197.032

Exact Mass：

195.963608

DSSTox ID：

DTXSID10694156

HScode：

2933399090

Characteristics

PSA：

36.7

XLogP3：

Density：

1.6±0.1 g/cm3

Boiling Point：

293.3°C at 760 mmHg

Flash Point：

131.2±25.9 °C

Refractive Index：

1.594

Safety Information

hazard class code：

22-37/38-41

safety instructions：

26-39

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (97.44%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE Use and Manufacturing

2, 5-Dibromo-4-methylpyridine(5.0 g, 19.9 mmol), copper cyanide (1.43 g, 15.9 mmol), sodium cyanide (0.801 g, 16.3 mmol) and dimethylformamide (30 mL) were combined in a sealed reaction vessel and heated at 158 5-bromo-4-methyl-pyridine-2-carbonitrile: To a solution of 2, 5-dibromo-4-methylpyridine (15 g, 59.8 mmol, Eq: 1.00) in DMF (100 ml) was added copper(I) cyanide (4.28 g, 47.8 mmol, Eq: 0.8) and sodium cyanide (2.34 g, 47.8 mmol, Eq: 0.8). The reaction mixture was refluxed for 20 hr at which point a precipitate formed. Upon cooling water was added and the mixture sonicated. The solids were filtered and washed with water. The resulting filtrate was extracted with EtOAc and the organic layers then combined, washed with water and brine, and concentrated under reduced pressure. The crude material was then purified by column chromatography (0-10percent EtOAc/Hex gradient) to give 5-bromo-4-methyl-pyridine-2-carbonitrile (5 g, 42.4percent yield) as a white solid.5-bromo-4-methyl-pyridine-2-carbonitrile:To a solution of 2, 5-dibromo-4-methylpyridine (15 g, 59.8 mmol, Eq: 1.00) in DMF (100 ml) was added copper(1) cyanide (4.28 g, 47.8 mmol, Eq: 0.8) and sodium cyanide (2.34 g, 47.8 mmol, Eq: 0.8). Into a 30 mL sealed tube purged and maintained with nitrogen, was placed tert- butyl (2S)-2-methylpiperazine-l-carboxylate (975 mg, 1.2 eq), 5-bromo-4-methylpyridine-2- carbonitrile (800 mg, 1 eq), Pd2(dba)3CHCl3 (841 mg, 0.2 eq), Xantphos (939 mg, 0.4 eq), ) CS2CO3 (3972 mg, 3 eq), dioxane (10 mL). The resulting solution was stirred for 2 h at l00C. The solids were filtered out. The filtrate was applied onto a silica gel column eluting with ethyl acetate/petroleum ether. This resulted in 500 mg (39%) of tert-butyl (2S)-4-(6-cyano-4- methylpyridin-3-yl)-2-methylpiperazine-l-carboxylate as yellow oil. LCMS: m/z = 317 [M+H]+.In a 5 mL vial, 2-[tert-butyl(dimethyl)silyl]oxypropylamine (CAS [1789680-15-4], 380 mg, 2 mmol, 2.0 eq), A mixture of

Computed Properties

Molecular Weight:197.03
XLogP3:2
Hydrogen Bond Acceptor Count:2
Exact Mass:195.96361
Monoisotopic Mass:195.96361
Topological Polar Surface Area:36.7
Heavy Atom Count:10
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

5-Bromo-4-methylpyridine-2-carbonitrile

CAS No.: 886364-86-9

Content: 99.00%

Inquiry
Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE -a

CAS No.: 886364-86-9

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high quality 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE 99% transparent liquid KANBEI

CAS No.: 886364-86-9

Grade: Industrial Grade

Content: 99%

Inquiry

Latest News on 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE

Learn More Other Chemicals

(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID

51485-76-8
Benadryl N-oxide hydrochloride

13168-00-8
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE

885275-59-2
(2-Bromophenyl)diphenylphosphine Formula

62336-24-7
1-Morpholinocyclopentene Formula

936-52-7
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula

168892-66-8
3-amino-5-bromopyridine-2-carboxylic acid Structure

870997-85-6
2-Amino-6-methylpyridine Structure

1824-81-3
What is 3-Bromo-2-methylthiophene

30319-05-2
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER

2026-42-8

Hot Searches: naf compound name; 1-butyne; h3bo3; enclomiphene buy; difluoroethane; ammonium sulfide

Guide of 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.