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GSK1904529A

GSK1904529A structure

CAS No:
1089283-49-7
Formula:
C44H47F2N9O5S
Chemical Name:
GSK1904529A
Synonyms:
GSK1904529A;GSK1904529A : IGF-IR, IGF-IIR inhibitor;N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-(methyloxy)benzamide;GSK 4529;N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)H-imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide;N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-(methyloxy)benzamide GSK 1904529A;GSK1904529A, >=98%;IGF-IR, IGF-IIR inhibitor
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc. IC50 value: 27/25 nM (IGF1R/IR) [1]Target: IGF1R/IRin vitro: GSK1904529A is a reversible, ATP-competitive inhibitor and has enzyme-inhibitor binding values against IGF-1R and IR with Ki of 1.6 nM and 1.3 nM, respectively. GSK1904529A potently inhibits the ligand-induced phosphorylation of IGF-1R and IR at concentration

N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide is a member of benzamides.

GSK1904529A Basic Attributes

Molecular Weight：

851.98

Exact Mass：

851.338867

DSSTox ID：

DTXSID70648776

Characteristics

PSA：

155

XLogP3：

6.8

Density：

1.39

Refractive Index：

1.672

Drug Information

MeSH Entry Terms：

GSK1904529A

GSK1904529A Use and Manufacturing

A selective inhibitor of IGF-1R and IR with IC50s of 27 nM and 25 nM, respectively.

Computed Properties

Molecular Weight:852.0
XLogP3:6.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:12
Exact Mass:851.33889313
Monoisotopic Mass:851.33889313
Topological Polar Surface Area:155
Heavy Atom Count:61
Complexity:1530
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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GSK1904529A

CAS No.: 1089283-49-7

Content: 99%

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