 Home > Encyclopedia > Biapenem

Biapenem

Biapenem structure

CAS No:
120410-24-4
Formula:
C15H18N4O4S
Chemical Name:
Biapenem
Synonyms:
5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium,6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-,inner salt;5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium,6-[[2-carboxy-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-,inner salt,[4R-[4α,5β,6β(R*)]]-;1-Azabicyclo[3.2.0]heptane,5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium deriv.;LJC 10627;L 627;6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a]-s-triazol-4-ium hydroxide,inner salt;CL 186815;Biapenem;Biapenern;CL 186-815;Omegacin;103939-78-2;133279-57-9
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Off-White SolidBiapenem was introduced in Japan as a parenteral treatment for bacterial infections. This new 1-β-methylcarbapenem can be prepared by reaction of commercially available 4-nitrobenzyl protected β-methylcarbapenem enolphosphate with mercapto bicyclotriazolium chloride, obtained in 11 steps starting from hydrazine, followed by deprotection of the carboxylic acid function.

Biapenem is a carbapenem antibiotic in which the azetidine and pyrroline rings carry 1-hydroxymethyl and pyrazolo[1,2-a][1,2,4]triazolium-6-ylthio substituents respectively. It has a role as an antibacterial drug. It is a member of carbapenems, a pyrazolotriazole and an organic sulfide.|Biapenem has been used in trials studying the treatment of Bacterial Infections.|Biapenem is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropeptidase-I and with less neurotoxicity.

Biapenem Basic Attributes

Molecular Weight：

350.39

Exact Mass：

350.104889

EC Number：

204-352-8

UNII：

YR5U3L9ZH1

DSSTox ID：

DTXSID5046435

NCI Thesaurus Code：

C72620

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

128

XLogP3：

1.4

Appearance：

white to beige

Melting Point：

265-271°C (dec.)

Refractive Index：

1.651

Water Solubility：

H2O: ≥5mg/mL (warmed)

Storage Conditions：

-20°C Freezer

Specific rotation：

D20 -32.9° (c = 0.5)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH：

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)

MeSH Entry Terms：

3-((6,7-dihydro-5H-pyrazolo(1,2-a)(1,2,4)triazol-4-ium-6-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3,2,0)hept-2-ene-2-carboxylate

Biapenem Use and Manufacturing

A carbepenem with antibacterial action

Computed Properties

Molecular Weight:350.4
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:350.10487624
Monoisotopic Mass:350.10487624
Topological Polar Surface Area:128
Heavy Atom Count:24
Complexity:609
Defined Atom Stereocenter Count:4
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Biapenem is a carbapenem antibiotic that exerts its antibacterial effect by inhibiting the synthesis of bacterial cell walls. It has broad-spectrum antibacterial activity against gram-positive and gram-negative aerobic and anaerobic bacteria. Biapenem is stable to human renal dehydropeptidase-I (DHP-I) and can be administered alone without the need for combination with DHP-I inhibitors.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Biapenem for injection
Ingredients	The main ingredient of this product is biapenem, without excipients. Chemical name: (-)6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt. Molecular formula: C15H18N4O4S Molecular weight: 350.40
Indication	When this product is used in combination with valproic acid, it may lead to a decrease in the blood concentration of valproic acid, which may cause recurrence of epilepsy. Therefore, this product should not be used in combination with valproic acid preparations.
Specifications	0.3g
Manufacturer	CSPC OUYI Pharmaceutical Co., Ltd.

Biapenem
Manufacturer	Zhuhai UNITED Laboratories Co., Ltd.

Biapenem for injection
Ingredients	The main ingredient of this product is biapenem, without excipients. Chemical name: (-)6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt. Molecular formula: C15H18N4O4S Molecular weight: 350.40
Indication	When this product is used in combination with valproic acid, it may lead to a decrease in the blood concentration of valproic acid, which may cause recurrence of epilepsy. Therefore, this product should not be used in combination with valproic acid preparations.
Specifications	0.3g
Manufacturer	CHIA TAI Tianqing Pharmaceutical Group Co., Ltd.

See More Related Drugs

Registered Holders

Amicogen(China) Biopharm Co., Ltd.

China
Active
CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

China
Active
Shandong Anhong Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Biapenem

BrightGene Health Technology Co., Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of APIs,Veterinary,Cosmetic Ingredients,Peptides,intermediates,food ingredients

High quality Biapenem 99% power GMP workshipHolypharm

CAS No.: 120410-24-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Dayang Chem (Hangzhou) Co.,Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of N-Diethyl-m-toluamide,6-Methyluracil,Anisole,4-Dimethoxybenzoic acid,CS (lacrimator),Daucosterol,N,N-Formylmorpholine,Epichlorohydrin,Tetramethylguanidine,Dimethicone,3

Biapenem Manufacturer/High quality/Best price/In stock

CAS No.: 120410-24-4

Inquiry
ROYAL PHARM Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of additives,pharmaceutical chemicals,organic intermediate,chemical intermediates,Pharmaceutical Intermediates,catalyst,API

Biapenem CAS No.120410-24-4

CAS No.: 120410-24-4

Grade: Pharmaceutical grade

Content: 99%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Crude grade of Biapenem120410-24-4

CAS No.: 120410-24-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high quality biapenem 99% transparent liquid KANBEI

CAS No.: 120410-24-4

Grade: Industrial Grade

Content: 99%

Inquiry