calcium trisodium pentetate
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calcium trisodium pentetate
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CAS No:
12111-24-9
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Formula:
C14H18CaN3NaO10(-2)
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Chemical Name:
calcium trisodium pentetate
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Synonyms:
calcium trisodium pentetate;Pentetate Calcium Trisodium;Calciate(3-), [N-[2-[bis[(carboxy-kO)Methyl]aMino-kN]ethyl]-N-[2-[[(carboxy-kO)Methyl](carboxyMethyl)aMino-kN]ethyl]glycinato(5-)-kN]-, sodiuM (1:3);CALCIUMDTPA;Calciate(3-), [N,N-bis[2-[bis(carboxymethyl) amino]ethyl]glycinato(5-)]-, trisodium;Calciate(3-), [N-[2-[bis[(carboxy-κO)methyl]amino-κN]ethyl]-N-[2-[[(carboxy-κO)methyl](carboxymethyl)amino-κN]ethyl]glycinato(5-)-κN]-, sodium (1:3);Pentetate sodium calcium CRS;calcium trisodium pentetate USP/EP/BP
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CAS No:
Description
Pentetate Calcium Trisodium is the trisodium salt form of calcium diethylene triamine pentaacetate (Ca-DTPA or pentetate calcium) with chelating activity. Upon administration, Ca-DTPA loses the Ca ion to form stable chelates with metal ions because DTPA has a higher affinity for heavy metal ions than for Ca ions. Specifically, this agent is able to bind to and form strong complexes with radioactive plutonium, americium, and cerium after internal contamination with any of these radionuclides thereby increasing their excretion.|An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.
Moderately toxic by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NazO and NO,. See also CALCIUM COMPOUNDS.
calcium trisodium pentetate Basic Attributes
451.38
497.03100
235-169-1
G79YN26H5B
TSCA listed
DTXSID8065248
C74576
Characteristics
182.71000
-6.90500
721.1ºC at 760mmHg
389.9ºC
9.53E-23mmHg at 25°C
LD50 i.p. in rats: 3.8 g/kg (Dagirmanjian)
Thermal decomposition releases toxic nitrogen oxides and sodium oxide fumes
2-8°C
Drug Information
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems. (See all compounds classified as Iron Chelating Agents.)|Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)|Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)
Ca-DTPA
calcium trisodium pentetate Use and Manufacturing
Chelating agent (plutonium).
Pentetate Trisodium Calcium is used as a local treatment to remove 90Y from a puncture wound and minimize 90Y-distribution to bone.
Calciate(3-), [N-[2-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]ethyl]-N-[2-[[(carboxy-.kappa.O)methyl](carboxymethyl)amino-.kappa.N]ethyl]glycinato(5-)-.kappa.N]-, sodium (1:3): ACTIVE
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:497.35
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:11
Exact Mass:497.0311175
Monoisotopic Mass:497.0311175
Topological Polar Surface Area:210
Heavy Atom Count:31
Complexity:454
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes
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