 Home > Encyclopedia > Pazufloxacin

Pazufloxacin

Pazufloxacin structure

CAS No:
127045-41-4
Formula:
C16H15FN2O4
Chemical Name:
Pazufloxacin
Synonyms:
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-,(3S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-,(S)-;(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid;T 3761;(-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid;Pazufloxacin
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Pazufloxacin is a fluoroquinolone with a 1-aminocyclopropyl substituent at C10 position. The presence of aminoacyl group at C-10 is a unique feature of the molecule imparting potent broad spectrum activity against gram-positive and gram-negative bacteria. This activity is based on the inhibition of bacterial DNA gyrase.

LSM-5745 is a member of quinolines.|Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol).

Pazufloxacin Basic Attributes

Molecular Weight：

318.3

Exact Mass：

318.30

EC Number：

1806241-263-5

UNII：

4CZ1R38NDI

DSSTox ID：

DTXSID5046697

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

92.9

XLogP3：

0.09

Appearance：

like white to light yellow crystalline

Density：

1.56

Melting Point：

269-271.5 °C

Boiling Point：

531.5±50.0 °C(Predicted)

Flash Point：

275.2±30.1 °C

Refractive Index：

1.692

Storage Conditions：

2-8°C

Vapor Pressure：

4E-12mmHg at 25°C

Toxicity：

LD50 i.v. in male mice: >500 mg/kg (Todo)

Specific rotation：

D25 -88.0° (c = 0.5 in 0.05N aq NaOH)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-34-11

safety instructions：

36/37-45-36/37/39-26-16

RTECS Number：

UU8815300

Marks：

Xn,C,F

Precautionary statement(s)：

P280

Hazard Statements：

H302-H312-H332

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)|Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)

MeSH Entry Terms：

10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido(1,2,3-d,e)(1,4)benzoxazinecarboxylic acid

Pazufloxacin Use and Manufacturing

antibactierial

Computed Properties

Molecular Weight:318.30
XLogP3:-0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:318.10158513
Monoisotopic Mass:318.10158513
Topological Polar Surface Area:92.9
Heavy Atom Count:23
Complexity:603
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ethyl acetate

Paraformaldehyde

Trifluoroacetic acid

Sodium sulfite

Recommended Suppliers of Pazufloxacin

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Pazufloxacin supplier Pharmaceutical API Antibiotic made in china

CAS No.: 127045-41-4

Inquiry