Tenofovir

White Crystalline SolidChEBI: A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxy ethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

• CAS No：

  147127-20-6

• Molecular Formula ：

  C9H14N5O4P

• Molecular Mass ：

  287.21

• Exact Mass ：

  287.078339

• PSA ：

  136

• LogP ：

  -1.6

• EINECS ：

  1308068-626-2

• InChIKeys ：

  SGOIRFVFHAKUTI-ZCFIWIBFSA-N

• H-bond Acceptor ：

  8

• H-bond Donor ：

  3

• SP3 ：

  0.44

• RBN ：

  5

• Appearance ：

  Solid

• Density ：

  1.79±0.1 g/cm3(Predicted)

• Melting Point ：

  276-280°C

• Bolling Point ：

  616°C

• Flash Point ：

  326.4±34.3 °C

• Refractive Index ：

  1.740

• Solubility ：

  H2O: 13.4 mg/mL (25 ºC)

• Storage Condition ：

  Store at -20°C

• Specific Rotation ：

  D +21° (c = 1 in 0.1M HCl)

• Packing Group ：

  III

• Hazard Class ：

  8

• HS Code ：

  29339900

• UN No. ：

  UN 3261 8/PG 2

• WGK_Germany ：

  3

• Risk Code ：

  R34:Causes burns.

• Safety Instructions ：

  S22-S26-S27-S36/37/39-S45

• RTECS No. ：

  SZ6563600

• Dangerous Mark ：

  C

• P Code ：

  P280, P305+P351+P338, P310

• Hazard Statements ：

  H318

Tenofovir is a drug used for the treatment of chronic heptatitis B as well as prevention and treatment of HIV/AIDS. It is a kind of nucleotide analog, acting as the reverse-transcriptase inhibitor (NtRTI). It inhibits the activity of HIV reverse transcriptase through competing with the natural substrate deoxyadenosine 5’-triphosphate, causing the termination of DNA chain.