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TSH-releasing hormone

TSH-releasing hormone structure

CAS No:
24305-27-9
Formula:
C16H22N6O4
Chemical Name:
TSH-releasing hormone
Synonyms:
L-Prolinamide,5-oxo-L-prolyl-L-histidyl-;Thyrotropin-releasing factor;5-Oxo-L-prolyl-L-histidyl-L-prolinamide;L-Pyroglutamyl-L-histidyl-L-prolinamide;L-Pyroglutamyl-L-histidyl-L-proline amide;Synthetic TRH;Synthetic thyrotropin-releasing hormone;(Pyro)-L-glutamic acid-L-histidine-L-proline-NH2;Synthetic TSH-releasing hormone;Synthetic TSH-releasing factor;Synthetic thyrotropin-releasing factor;Lopremone;FDA 1725;Synthetic TRF;Protirelin;TSH-releasing factor;Thyroliberin;TRH;TRF;Thyrotropin-releasing hormone;Thyrotropic hormone-releasing factor;TSH-releasing hormone;Thyrotropic hormone-releasing hormone;Thyrotropic-releasing factor;TSH-RF;Thyroid-stimulating hormone-releasing factor;Thyrotropic releasing hormone;Rifathyroin;Ro 8-6270/9;Thyroid releasing hormone;Relefact TRH;Thyrefact;Rifotironin;Antepan;Prem;Thypinone;Stimu TSH;Abbott 38579;83: PN: US20090175821 PAGE: 403 claimed protein;252: PN: WO2010033207 SEQID: 378 claimed protein;9015-91-2;22365-17-9;22365-02-2;39422-15-6;77666-61-6
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide.|Protirelin is the pharmaceutically available synthetic analogue of the endogenous peptide thyrotropin-releasing hormone (TRH). It is a tri-peptide tropic hormone, released by the hypothalamus, that stimulates the release of Thyroid Stimulating Hormone (TSH) and prolactin from the anterior pituitary. Although not currently available in any FDA-approved product, protirelin is a component of the TRH Test where it is used to test the response of the anterior pituitary gland in conditions such as secondary hypothyroidism and acromegaly.|A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.

TSH-releasing hormone Basic Attributes

Molecular Weight：

362.38

Exact Mass：

362.38

EC Number：

246-143-4

UNII：

5Y5F15120W

DSSTox ID：

DTXSID0023533

ATC Code：

V - Various

Characteristics

PSA：

150

XLogP3：

-2.43

Appearance：

powder

Density：

1.5±0.1 g/cm3

Boiling Point：

942.1±65.0 °C at 760 mmHg

Flash Point：

523.6±34.3 °C

Refractive Index：

1.617

Water Solubility：

H2O: 10 mg/mL, clear, colorless

Storage Conditions：

−20°C

Vapor Pressure：

0mmHg at 25°C

Collision Cross Section：

181 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|184.12 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|187.07 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|179.2 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|182.4 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|184.5 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|183.2 Å² [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|183.2 Å² [M-2H+Na]-

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

TW3580000

Precautionary statement(s)：

P261, P271, P304+P312, P304+P340, P312

Hazard Statements：

H332

GHS Classification：

|Warning|H332 (94.12%): Harmful if inhaled [Warning Acute toxicity, inhalation]|P261, P271, P304+P312, P304+P340, and P312|Aggregated GHS information provided by 17 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects. (See all compounds classified as Hormones.)

MeSH Entry Terms：

Abbott 38579

TSH-releasing hormone Use and Manufacturing

Uses

prothyrotropin

Manufacturing Info：

Transferrin: ACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:362.38
XLogP3:-2.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:362.17025320
Monoisotopic Mass:362.17025320
Topological Polar Surface Area:150
Heavy Atom Count:26
Complexity:597
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Prorelin
Manufacturer	Hybio Pharmaceutical Co., Ltd.

Prorelin

Prorelin for injection
Indication	Its regulation of TSH is affected by dopamine and norepinephrine. Both β-receptor blockers and levodopamine can inhibit it, and bromocriptine also affects its effect.
Specifications	0.5mg
Manufacturer	Livzon (GROUP) Pharmaceutical FACTORY

Registered Holders

Shanghai Livzon Pharmaceutical Co., Ltd.

China
Active
Hybio Pharmaceutical Co., Ltd.

China
Active
Senn Chemicals AG

Switzerland
Inactive

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Guide of TSH-releasing hormone

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

TSH-releasing hormone

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