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Tilorone

Tilorone structure

CAS No:
27591-97-5
Formula:
C25H34N2O3
Chemical Name:
Tilorone
Synonyms:
9H-Fluoren-9-one,2,7-bis[2-(diethylamino)ethoxy]-;2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one;Tilorone;Bis-DEAE-fluorenone;2,7-Bis-DEAE-fluorenone;2,7-Bis(2-diethylaminoethoxy)fluoren-9-one
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Tilorone is a member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug. It has a role as an antiviral agent, an interferon inducer, an antineoplastic agent, an anti-inflammatory agent and a nicotinic acetylcholine receptor agonist. It is a member of fluoren-9-ones, a tertiary amino compound, an aromatic ether and a diether. It is a conjugate base of a tilorone(2+).|Tilorone is a orally available small molecule interferon inducer that is used as an antiviral agent.|An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.

Tilorone Basic Attributes

Molecular Weight：

410.55

Exact Mass：

410.55

EC Number：

1806241-263-5

UNII：

O6W7VEW6KS

NSC Number：

759311

DSSTox ID：

DTXSID1045958

NCI Thesaurus Code：

C73335

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

XLogP3：

5.25

Density：

1.1±0.1 g/cm3

Boiling Point：

552.3±50.0 °C at 760 mmHg

Flash Point：

287.8±30.1 °C

Refractive Index：

1.564

Vapor Pressure：

3.05E-12mmHg at 25°C

Collision Cross Section：

219.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)|Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons. (See all compounds classified as Interferon Inducers.)

MeSH Entry Terms：

Amiksin

Tilorone Use and Manufacturing

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:410.5
XLogP3:4.7
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:410.25694295
Monoisotopic Mass:410.25694295
Topological Polar Surface Area:42
Heavy Atom Count:30
Complexity:477
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Hot Sale Tilorone Dihydrochloride CAS: 27591-69-1 with Good Quality hot

CAS No.: 27591-97-5

Grade: Pharmaceutical Grade

Content: 99%

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