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Rosuvastatin

Rosuvastatin structure

CAS No:
287714-41-4
Formula:
C22H28FN3O6S
Chemical Name:
Rosuvastatin
Synonyms:
6-Heptenoic acid,7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-,(3R,5S,6E)-;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid;Rosuvastatin;ZD 4522;(E)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)(methyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid;X-Plended;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoic acid;AZD-4522;AZD4522;AZD 4522;1354641-86-3
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Rosuvastatin is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM. IC50 Value: 11 nM [1]Target: HMG-CoA reductasein vitro: Rosuvastatin is relatively hydrophilic and is highly selective for hepatic cells; its uptake is mediated by the liver-specific organic anion transporter OATP-C. Rosuvastatin is a high-affinity substrate for OATP-C with apparent association constant of 8.5 μM [2]. Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50

Rosuvastatin Basic Attributes

Molecular Weight：

481.54

Exact Mass：

481.54

EC Number：

1806241-263-5

Characteristics

PSA：

152.13000

XLogP3：

2.14780

Appearance：

Solid

Density：

1.368 g/cm3

Melting Point：

161.9 °C

Boiling Point：

745.6ºC at 760 mmHg

Flash Point：

404.7ºC

Refractive Index：

1.597

Water Solubility：

Sparingly soluble in water

Vapor Pressure：

5.27X10-19 mm Hg at 25 °C (est)

Safety Information

Stability/Shelf Life：

Stable under recommended storage conditions. /Rosuvastatin calcium/

Rosuvastatin Use and Manufacturing

Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.

Computed Properties

Molecular Weight:481.5
XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Exact Mass:481.16828496
Monoisotopic Mass:481.16828496
Topological Polar Surface Area:149
Heavy Atom Count:33
Complexity:767
Defined Atom Stereocenter Count:2
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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