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Etofibrate

Etofibrate structure

CAS No:
31637-97-5
Formula:
C18H18ClNO5
Chemical Name:
Etofibrate
Synonyms:
3-Pyridinecarboxylic acid,2-[2-(4-chlorophenoxy)-2-methyl-1-oxopropoxy]ethyl ester;Nicotinic acid,2-hydroxyethyl ester 2-(p-chlorophenoxy)-2-methylpropionate (ester);Etofibrate;Lipo-Merz;Ethofibrate;Tricerol
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Etofibrate is the ethandiol-1,2 diester of the nicotinic and clofibric acids. Etofibrate has been shown to be a potent hypolipidemic agent in animal and human.

Etofibrate is a monocarboxylic acid.|Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.|Etofibrate is an orally-available combination of clofibrate and niacin linked together by an ester bond. In the body clofibrate and niacin separate, acting as a controlled-release formulation.

Etofibrate Basic Attributes

Molecular Weight：

363.79

Exact Mass：

363.79

EC Number：

250-743-1

UNII：

23TF67G79M

DSSTox ID：

DTXSID80185521

NCI Thesaurus Code：

C65588

ATC Code：

C - Cardiovascular system

HScode：

2933399090

Characteristics

PSA：

74.7

XLogP3：

3.5

Appearance：

White to off-white solid

Density：

1.3±0.1 g/cm3

Melting Point：

100 °C

Boiling Point：

486.8ºC at 760 mmHg

Flash Point：

248.2±25.9 °C

Refractive Index：

1.555

Water Solubility：

7.276mg/L(room temperature)

Storage Conditions：

Refrigerator

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH：

Substances used to lower plasma cholesterol levels. (See all compounds classified as Anticholesteremic Agents.)|Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)

MeSH Entry Terms：

etofibrate

Etofibrate Use and Manufacturing

Antilipemic; reducing lipid levels in the blood.

Computed Properties

Molecular Weight:363.8
XLogP3:3.5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:363.0873504
Monoisotopic Mass:363.0873504
Topological Polar Surface Area:74.7
Heavy Atom Count:25
Complexity:449
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Manufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acid

31637-97-5 2-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxyethyl pyridine-3-carboxylate

CAS No.: 31637-97-5

Grade: Industrial Grade

Content: 95%

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