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N-Acetylprocainamide

N-Acetylprocainamide structure

CAS No:
32795-44-1
Formula:
C15H23N3O2
Chemical Name:
N-Acetylprocainamide
Synonyms:
Benzamide,4-(acetylamino)-N-[2-(diethylamino)ethyl]-;4-(Acetylamino)-N-[2-(diethylamino)ethyl]benzamide;N-Acetylprocainamide;N-Acetylprocaine amide;Acecainide;N-Acetylnovocainamide;NAPA
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.

N-acetylprocainamide is a benzamide obtained via formal condensation of 4-acetamidobenzoic acid and 2-(diethylamino)ethylamine. It has a role as an anti-arrhythmia drug. It is a member of benzamides and a member of acetamides.|A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.

N-Acetylprocainamide Basic Attributes

Molecular Weight：

277.36

Exact Mass：

277.36

UNII：

910Q707V6F

DSSTox ID：

DTXSID6048414

HScode：

2924299090

Characteristics

PSA：

61.4

XLogP3：

2.18050

Density：

1.097g/cm3

Melting Point：

210 °C

Boiling Point：

500ºC at 760mmHg

Flash Point：

256.2ºC

Water Solubility：

soluble1%, clear, colorless to faintly yellow (1N HCl)

Storage Conditions：

-20°C

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

AE1974350

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

Metabolism/Metabolites：

Acecainide is a known human metabolite of Procainamide.

MeSH Entry Terms：

Acecainide

N-Acetylprocainamide Use and Manufacturing

antiprotozoal

Computed Properties

Molecular Weight:277.36
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:277.17902698
Monoisotopic Mass:277.17902698
Topological Polar Surface Area:61.4
Heavy Atom Count:20
Complexity:308
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes