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Etidocaine

Etidocaine structure

CAS No:
36637-18-0
Formula:
C17H28N2O
Chemical Name:
Etidocaine
Synonyms:
Butanamide,N-(2,6-dimethylphenyl)-2-(ethylpropylamino)-;Butanamide,N-(2,6-dimethylphenyl)-2-(ethylpropylamino)-,(±)-;N-(2,6-Dimethylphenyl)-2-(ethylpropylamino)butanamide;(±)-2-(N-Ethyl-N-propylamino)-2′,6′-butyroxylidide;Etidocaine;2-(N-Ethylpropylamino)-2′,6′-butyroxylidide;60108-68-1
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

ChEBI: An amino acid amide in which 2-[ethyl(propyl)amino]butanoic acid and 2,6-dimethylaniline have combined to form the amide bond. Used as a local anaesthetic (amide caine), it has rapid onset and long action properties, similar to bupivacaine, and is given b injection during surgical procedures and during labour and delivery.

Etidocaine is an amino acid amide in which 2-[ethyl(propyl)amino]butanoic acid and 2,6-dimethylaniline have combined to form the amide bond. Used as a local anaesthetic (amide caine), it has rapid onset and long action properties, similar to bupivacaine, and is given by injection during surgical procedures and during labour and delivery. It has a role as a local anaesthetic.|Etidocaine is marketed under the name Duranest. It is an injectable local anesthetic during surgery, labor, and delivery. Etidocaine has a long duration of activity, but has the main disadvantage of increased bleeding during oral surgery.|A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.

Etidocaine Basic Attributes

Molecular Weight：

276.421

Exact Mass：

276.42

EC Number：

253-143-8

UNII：

Y83XVY9AQ8|K9D2CE52PU

DSSTox ID：

DTXSID1023027

ATC Code：

N - Nervous system

Characteristics

PSA：

32.3

XLogP3：

3.77

Density：

1.0±0.1 g/cm3

Melting Point：

203-203.5

Boiling Point：

389.7±30.0 °C at 760 mmHg

Flash Point：

189.5±24.6 °C

Refractive Index：

1.532

Drug Information

MeSH：

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

MeSH Entry Terms：

2-(Ethylpropylamino)-2',6'-butyroxylidide

Etidocaine Use and Manufacturing

Uses

Anesthetic (local).

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Pharmaceuticals

Computed Properties

Molecular Weight:276.4
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:276.220163521
Monoisotopic Mass:276.220163521
Topological Polar Surface Area:32.3
Heavy Atom Count:20
Complexity:283
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes