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Thiocolchicoside

Thiocolchicoside structure

CAS No:
602-41-5
Formula:
C27H33NO10S
Chemical Name:
Thiocolchicoside
Synonyms:
Acetamide,N-[(7S)-3-(β-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-;Colchicoside,10-thio-;Acetamide,N-[3-(β-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-,(S)-;Colchicoside,thio-;Benzo[a]heptalene,acetamide deriv.;N-[(7S)-3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide;R 271;Thiocolchicoside;Coltramyl;Muscoril;2-Demethoxy-2-glucosidoxythiocolchicine;Miorel;Coltrax;NSC 147755;Miotens;Thiocholshikoside;Etoshine MR;24568-37-4;27133-72-8;1309596-52-8
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties[1].

Thiocolchicoside Basic Attributes

Molecular Weight：

563.62

Exact Mass：

563.62

EC Number：

210-017-7

Characteristics

PSA：

189

XLogP3：

0.34

Density：

1.5±0.1 g/cm3

Melting Point：

220 °C (decomp)

Boiling Point：

929.624

Flash Point：

516.0±34.3 °C

Refractive Index：

1.657

Water Solubility：

10 mg/mL

Storage Conditions：

Refrigerator

Toxicity：

LD50 intraperitoneal in mouse: 1mg/kg

Specific rotation：

D -609° (water), -240° (ethanol)

PKA：

12.74None

Safety Information

Transport codes：

NONH for all modes of transport

RTECS Number：

AC2976015

Precautionary statement(s)：

P301 + P312 + P330-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

Thiocolchicoside Use and Manufacturing

A GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects.

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Thiocolchicoside

CAS No.: 602-41-5

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CAS No.: 602-41-5

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