Propoxycaine

294.392

294.39

201-670-9

EPD1EH7F53

DTXSID6047866

C66492

2922509090

64.8

3.13740

1.065g/cm3

146-151

434.4ºC at 760 mmHg

216.5ºC

1.527

10 µg/mL in water

The toxicity of this medication (7-8 times higher than that of procaine), has prevented this medication from being used on its own. Ester-type local anesthetics are much more likely to cause an allergic reaction compared to the amide-group local anesthetics because of the formation of PABA (Para-aminobenzoic acid) during the metabolic process. PABA may cause allergic reactions that range from urticaria to anaphylaxis. PABA is also formed during the metabolism of methylparaben (a common preservative) that is normally found in multi-dose vials including lidocaine (MDV) (amide-type local anesthetic).

Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures. It has been combined with procaine to accelerate its onset of action and provide longer-lasting anesthetic effect. It was produced for use when amide local anesthetics were contraindicated due to allergy or when several amide anesthetics were unsuccessful.

Propoxycaine is a local anesthetic which acts to decrease nerve impulses and therefore pain sensation during dental procedures.

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

Renal|Via the kidneys, primarily hydrolyzed.

This drug his hydrolyzed in both the plasma and the liver by plasma esterases.

Propoxycaine is a para-aminobenzoic acid ester with local anesthetic activity. Propoxycaine binds to and blocks voltage-gated sodium channels, thereby inhibiting the ionic flux essential for the conduction of nerve impulses. This results in a loss of sensation. In one study, propoxycaine hydrochloride increased annular lipid fluidity in cell lipid bilayers and had a greater fluidizing effect on the inner monolayer than that of the outer monolayer. This may further confirm its role in modulating neural impulses.

Hydrochloride, Propoxycaine