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Raltegravir

Raltegravir structure

Raltegravir 

structure
  • CAS No:

    518048-05-0

  • Formula:

    C20H21FN6O5

  • Chemical Name:

    Raltegravir

  • Synonyms:

    4-Pyrimidinecarboxamide,N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-;N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide;N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-1,6-dihydropyrimidine-4-carboxamide;Raltegravir;5-Hydroxy-2-[1-[[(5-Methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]-1-methylethyl]-N-(4-fluorobenzyl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide;RAL

  • Categories:

    Active Pharmaceutical Ingredients  >  Synthetic Anti-infective Drugs

Description

Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.

Raltegravir Basic Attributes

444.42

444.42

1312995-182-4

Characteristics

150

1.1

1.5±0.1 g/cm3

216 °C @ Solvent: Isopropanol

1.651

In water, 5.39X10+4 mg/L at 25 deg C (est)

Store chewable tablets in the original package with the bottle tightly closed. Keep the desiccant in the bottle to protect from moisture.

4.5X10-22 mm Hg at 25 deg C (est)

Raltegravir Use and Manufacturing

Raltegravir (MK-0518, Isentress) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectively.

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