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Pipecuronium bromide

Pipecuronium bromide structure

CAS No:
52212-02-9
Formula:
C35H62N4O4.2Br
Chemical Name:
Pipecuronium bromide
Synonyms:
Piperazinium,4,4′-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1,1-dimethyl-,bromide (1:2);Piperazinium,4,4′-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1,1-dimethyl-,dibromide;Pipecuronium bromide;RGH 1106;Arduan;Pipecurium bromide;67880-85-7;84307-15-3
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitive nAChR antagonist with a Kd of 3.06 μM[1][2][3][4][5].

Pipecuronium bromide is a steroid ester.|A piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent (NEUROMUSCULAR NONDEPOLARIZING AGENTS). It is used as a muscle relaxant during ANESTHESIA and surgical procedures.

Pipecuronium bromide Basic Attributes

Molecular Weight：

762.69918

Exact Mass：

760.31400

EC Number：

257-740-4

UNII：

R6ZTY81RE1

DSSTox ID：

DTXSID8023478

ATC Code：

M - Musculo-skeletal system

HScode：

29322980

Characteristics

PSA：

59.08000

Appearance：

Density：

1.329

Melting Point：

262-264 °C (decomp)

Toxicity：

LD50 in mice, rats (mg/kg): 29.7, 172.6 i.v.; 70.6, 449.6 i.p.; 60.5, 455.8 s.c. (Kárpáti, Biro)

Specific rotation：

D25 +8.1° (c = 1 in water)

Safety Information

wgk germany：

hazard class code：

R36/37/38:Irritating to eyes, respiratory system and skin .

safety instructions：

S26-S36

RTECS Number：

GN6820000

Marks：

GHS Classification：

|Danger|H300 (94.12%): Fatal if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 17 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. (See all compounds classified as Neuromuscular Nondepolarizing Agents.)|Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses. (See all compounds classified as Nicotinic Antagonists.)

MeSH Entry Terms：

Arduan

Pipecuronium bromide Use and Manufacturing

Uses

Pipecuronium Bromide is a muscle relaxant and an anaesthesia used in patients undergoing coronary artery bypass graft surgery. Non-depolarizing muscle relaxants, different dosages, can produce different effects and durations. It is a safe and effective medicine. Used for tracheal intubation, striated muscle relaxation, and general anesthesia during artificial respiration.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:762.7
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:762.31173
Monoisotopic Mass:760.31378
Topological Polar Surface Area:59.1
Heavy Atom Count:45
Complexity:1060
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Material

Magnesium sulfate heptahydrate

Tetrahydrofuran

Hexane

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pipecuronium
Manufacturer	Sichuan Tiandao Pharmaceutical Co., Ltd.

Pipecuronium Bromide for Injection
Specifications	4 mg/vial

Pipecuronium Bromide for Injection
Ingredients	Chemical name: 2β, 6β-di(4-dimethylpiperazinyl)-3α, 17β-diethylacyloxy-5α-androstane dibromide Chemical structure: Molecular formula: C35H62Br2N4O4 Molecular weight: 762.7 Excipients: Mannitol
Indication	The following drugs may affect the intensity and/or duration of action of non-depolarizing neuromuscular blocking drugs: 1. Enhance and/or prolong the action (1) Inhaled anesthetics (halothane, methoxyflurane, ether, enflurane, isoflurane, cyclopropane) (2) Intravenous anesthetics (ketamine, fentanyl, propanide, barbiturates, pyrimethamine) (3) High-dose local anesthetics (4) Other non-depolarizing muscle relaxants, pre-administration of succinylcholine (5) Certain antibiotics (aminoglycosides and peptide antibiotics, imidazoles, metronidazole, etc.) (6 ) Diuretics, β-adrenergic receptor blockers, vitamin B1. Monoamine oxidase inhibitors, guanidines, protamine, α-adrenergic receptor blockers, calcium antagonists, magnesium salts (7) Most antiarrhythmic drugs, including quinidine and intravenous lidocaine, enhance the blocking effect of non-depolarizing muscle relaxants 2. Changes in action Long-term use of corticosteroids, neostigmine, edrophonium chloride, pyridostigmine, norepinephrine, azathioprine, theophylline before surgery, and potassium chloride, sodium chloride, and calcium chloride before surgery. Depolarizing muscle relaxants weaken the effect of non-depolarizing muscle relaxants. 3. Uncertain reactions The use of depolarizing muscle relaxants after pipecuronium can cause an increase or decrease in neuromuscular blocking effects (depending on the dose, application time and individual sensitivity). 4. Others It is not recommended to mix pipecuronium with other solutions or drugs in the same syringe or infusion bag.
Specifications	4mg
Manufacturer	Sichuan Credit Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Luzhou Kereide Pharmaceutical Co., Ltd.

China
Active
GEDEON RICHTER LTD

United States
Inactive

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