 Home > Encyclopedia > Theofibrate

Theofibrate

Theofibrate structure

CAS No:
54504-70-0
Formula:
C19H21ClN4O5
Chemical Name:
Theofibrate
Synonyms:
Propanoic acid,2-(4-chlorophenoxy)-2-methyl-,2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester;ML 1024;Etofylline clofibrate;Duolip;Theofibrate;Etophylline clofibrate;Ethophylline clofibrate;NSC 234348;2-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Etofylline clofibrate has ypolipidemic and antithrombotic effect. Etofylline clofibrate has an agonistic interaction with intimal PGI2[1].

Etofylline clofibrate is an oxopurine.

Theofibrate Basic Attributes

Molecular Weight：

420.85

Exact Mass：

420.85

EC Number：

259-191-6

UNII：

14UH1JQP6L

NSC Number：

234348

DSSTox ID：

DTXSID0023032

Characteristics

PSA：

XLogP3：

2.75

Density：

1.4±0.1 g/cm3

Melting Point：

133-135 °C

Boiling Point：

615.8±65.0 °C at 760 mmHg

Flash Point：

326.2±34.3 °C

Refractive Index：

1.618

Toxicity：

LD50 in mice, rats, dogs (g/kg): 11.7, 17.0, >10.0 orally (Metz et al.)

Drug Information

MeSH：

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)|Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells. (See all compounds classified as Radiation-Sensitizing Agents.)|Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)

MeSH Entry Terms：

4-chlorophenoxyisobutyrate theophylline-7-ethyl ester

Theofibrate Use and Manufacturing

Hypolipidemic drugs.

Computed Properties

Molecular Weight:420.8
XLogP3:2.3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:420.1200475
Monoisotopic Mass:420.1200475
Topological Polar Surface Area:94
Heavy Atom Count:29
Complexity:653
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

No specific information provided

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Yiduode
Manufacturer	China Resources Double-Crane Pharmaceutical Co., Ltd.

Registered Holders

China Resources Double-Crane Pharmaceutical Co., Ltd.

China
Active