 Home > Encyclopedia > Brodimoprim

Brodimoprim

Brodimoprim structure

CAS No:
56518-41-3
Formula:
C13H15BrN4O2
Chemical Name:
Brodimoprim
Synonyms:
2,4-Pyrimidinediamine,5-[(4-bromo-3,5-dimethoxyphenyl)methyl]-;5-[(4-Bromo-3,5-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine;Ro 10-5970;Brodimoprim;Hyprim;Ro 105970;Unitrim;(2,4-diamino-5-(4-bromo-3,5-dimethoxybenzylpyrimidine);2,4-diamino-5-(4-bromo-3,5-dimethoxybenzyl) pyrimidine
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Off-White to Pale Yellow Solid

Brodimoprim is an aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an antiinfective agent and an antibacterial drug. It is an aminopyrimidine, a member of bromobenzenes and a member of methoxybenzenes.

Brodimoprim Basic Attributes

Molecular Weight：

339.1878

Exact Mass：

339.19

EC Number：

260-238-8

UNII：

V1YC7T6LLI

DSSTox ID：

DTXSID20205070

ATC Code：

J - Antiinfectives for systemic use

HScode：

2933599090

Characteristics

PSA：

96.3

XLogP3：

1.43

Density：

1.657 g/cm³ @ Temp: -160 °C

Melting Point：

225-228 °C

Boiling Point：

563.8±60.0 °C at 760 mmHg

Flash Point：

294.7±32.9 °C

Refractive Index：

1.646

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)|Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Folic Acid Antagonists.)

MeSH Entry Terms：

2,4-diamino-5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine

Brodimoprim Use and Manufacturing

A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.

Computed Properties

Molecular Weight:339.19
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:338.03784
Monoisotopic Mass:338.03784
Topological Polar Surface Area:96.3
Heavy Atom Count:20
Complexity:296
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Brodimoprim

Greenbo Biochem Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED Intermediates

Brodimoprim 99% high purity certified Professional Producer Greenbo

CAS No.: 56518-41-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry