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Cadralazine

Cadralazine structure

CAS No:
64241-34-5
Formula:
C12H21N5O3
Chemical Name:
Cadralazine
Synonyms:
Hydrazinecarboxylic acid,2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-,ethyl ester;ISF 2469;Cadralazine;DC 826;CGP 18684E;Presmode;Cadral;Cadraten;Cadrilan
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Description

Cadralazine is an organic molecular entity.

Cadralazine Basic Attributes

Molecular Weight：

283.33

Exact Mass：

283.33

DSSTox ID：

DTXSID4048725

ATC Code：

C - Cardiovascular system

Characteristics

PSA：

99.6

XLogP3：

1.22060

Density：

1.253 g/cm3

Melting Point：

160-162 °C

Boiling Point：

425.88°C (rough estimate)

Refractive Index：

1.59

Toxicity：

Oral-rat LD50: 2060 mg/kg; Oral-Mouse LD50: 825 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxide fumes

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

cadralazine

Cadralazine Use and Manufacturing

It relaxes the arterial smooth muscle and reduces the peripheral vascular resistance to lower blood pressure. Used for high blood pressure.

Computed Properties

Molecular Weight:283.33
XLogP3:1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:283.16443955
Monoisotopic Mass:283.16443955
Topological Polar Surface Area:99.6
Heavy Atom Count:20
Complexity:292
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes