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Flosequinan

Flosequinan structure

CAS No:
76568-02-0
Formula:
C11H10FNO2S
Chemical Name:
Flosequinan
Synonyms:
4(1H)-Quinolinone,7-fluoro-1-methyl-3-(methylsulfinyl)-;7-Fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone;BTS 49465;Flosequinan;Manoplax;BTS 49037;Flosequinon;BTS 49-465;156042-07-8
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Flosequinan is a member of quinolines.|Flosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due to increased mortality in chronic heart failure patients, found in drug trials.

Flosequinan Basic Attributes

Molecular Weight：

239.27

Exact Mass：

239.27

UNII：

6NB119DLU7

DSSTox ID：

DTXSID1048833

ATC Code：

C - Cardiovascular system

HScode：

2933499090

Characteristics

PSA：

56.6

XLogP3：

2.28070

Density：

1.44g/cm3

Melting Point：

226-228 °C

Boiling Point：

423.1ºC at 760 mmHg

Flash Point：

209.7ºC

Refractive Index：

1.654

Drug Information

MeSH：

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

Metabolism/Metabolites：

Flosequinan has known human metabolites that include flosequinan sulfone.

MeSH Entry Terms：

7-fluoro-1-methyl-3-methylsulfinyl-4-quinoline

Flosequinan Use and Manufacturing

Fluoroquinolones without antibacterial effect can directly dilate veins and arteries, thereby reducing preload and afterload. It has an inhibitory effect on inositol phosphate and can make the calcium stored in the cell flow. There are also some positive muscle strength effects. Used for patients with congestive heart failure that does not work on diuretics, those who cannot tolerate ACE inhibitors, or those who have ACE inhibitors in the treatment regimen and cannot be cured.

Computed Properties

Molecular Weight:239.27
XLogP3:1.1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:239.04162790
Monoisotopic Mass:239.04162790
Topological Polar Surface Area:56.6
Heavy Atom Count:16
Complexity:369
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Dimethyl sulfate