 Home > Encyclopedia > Ramiprilat

Ramiprilat

Ramiprilat structure

CAS No:
87269-97-4
Formula:
C21H28N2O5
Chemical Name:
Ramiprilat
Synonyms:
Cyclopenta[b]pyrrole-2-carboxylic acid,1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-,(2S,3aS,6aS)-;Cyclopenta[b]pyrrole-2-carboxylic acid,1-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]octahydro-,[2S-[1[R*(R*)],2α,3aβ,6aβ]]-;(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid;HOE 498 diacid;Ramipril diacid;Ramiprilat;Ramiprilate
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

White to Off-White Solid

Ramiprilat is a dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a drug metabolite, a cardioprotective agent, a matrix metalloproteinase inhibitor and a bradykinin receptor B2 agonist. It is a cyclopentapyrrole, an azabicycloalkane, a dipeptide and a dicarboxylic acid.|The active metabolite of the prodrug [Ramipril].|Ramiprilat is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of ramiprilat is as an Angiotensin-converting Enzyme Inhibitor.|Ramiprilat is a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Ramiprilat inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and leads to vasodilation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis.

Ramiprilat Basic Attributes

Molecular Weight：

388.46

Exact Mass：

388.46

UNII：

6N5U4QFC3G

NCI Thesaurus Code：

C72911

HScode：

3004909090

Characteristics

PSA：

107

XLogP3：

2.53

Appearance：

white to off-white solid

Density：

1.3±0.1 g/cm3

Melting Point：

109 °C

Boiling Point：

632.2±55.0 °C at 760 mmHg

Flash Point：

336.2±31.5 °C

Refractive Index：

1.583

Storage Conditions：

Refrigerator, Under Inert Atmosphere

Safety Information

hazard class code：

36/38

safety instructions：

26-37/39

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)

MeSH Entry Terms：

ramiprilat

Ramiprilat Use and Manufacturing

Uses

A metabolite of Ramipril (R111000).

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:388.5
XLogP3:0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:388.19982200
Monoisotopic Mass:388.19982200
Topological Polar Surface Area:107
Heavy Atom Count:28
Complexity:589
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Ramiprilat

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Ramiprilat

CAS No.: 87269-97-4

Content: 99.00%

Inquiry
Cuicheng Biomedical Technology Contact Supplier

CN
YRS

Business licensed Certified factory

Manufactory Supplier of Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5,Ginsenoside Rg5,Ginsenoside Rh2,Protopanaxatriol,Epmedin C,Icariin,Icaritin,Baohuoside I,Total Ginsenosides,Total Ginsenosides from Ginseng Stems And Leaves,Oridonin,Oleuropein,Curcumin,(20)-Ginsenoside Rg3,(20)-Protopanaxadiol

Ramiprilat

Unit Price: nullnull /null null

CAS No.: 87269-97-4

Grade: Industrial Grade

Content: 98%

Inquiry

Learn More Other Chemicals

Linoleic acid

60-33-3
Puerarin

3681-99-0
Sitagliptin

486460-32-6
2-Butyl-4-chloro-5-formylimidazole Formula

83857-96-9
Barnidipine Formula

104713-75-9
Benidipine Formula

105979-17-7
Semotiadil Structure

116476-13-2
Tirofiban Structure

144494-65-5
What is Niludipine

22609-73-0
What is Cinepazide

23887-46-9

Hot Searches: phenol price; quartz chemicals; elanopril; calcium clorate; acetic acid price; johnson matthey chemical products

Guide of Ramiprilat

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

Ramiprilat

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.