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Ramiprilat

Ramiprilat structure

CAS No:
87269-97-4
Formula:
C21H28N2O5
Chemical Name:
Ramiprilat
Synonyms:
Cyclopenta[b]pyrrole-2-carboxylic acid,1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-,(2S,3aS,6aS)-;Cyclopenta[b]pyrrole-2-carboxylic acid,1-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]octahydro-,[2S-[1[R*(R*)],2α,3aβ,6aβ]]-;(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid;HOE 498 diacid;Ramipril diacid;Ramiprilat;Ramiprilate
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

White to Off-White Solid

Ramiprilat is a dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a drug metabolite, a cardioprotective agent, a matrix metalloproteinase inhibitor and a bradykinin receptor B2 agonist. It is a cyclopentapyrrole, an azabicycloalkane, a dipeptide and a dicarboxylic acid.|The active metabolite of the prodrug [Ramipril].|Ramiprilat is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of ramiprilat is as an Angiotensin-converting Enzyme Inhibitor.|Ramiprilat is a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Ramiprilat inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and leads to vasodilation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis.

Ramiprilat Basic Attributes

Molecular Weight：

388.46

Exact Mass：

388.46

UNII：

6N5U4QFC3G

NCI Thesaurus Code：

C72911

HScode：

3004909090

Characteristics

PSA：

107

XLogP3：

2.53

Appearance：

white to off-white solid

Density：

1.3±0.1 g/cm3

Melting Point：

109 °C

Boiling Point：

632.2±55.0 °C at 760 mmHg

Flash Point：

336.2±31.5 °C

Refractive Index：

1.583

Storage Conditions：

Refrigerator, Under Inert Atmosphere

Safety Information

hazard class code：

36/38

safety instructions：

26-37/39

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)

MeSH Entry Terms：

ramiprilat

Ramiprilat Use and Manufacturing

Uses

A metabolite of Ramipril (R111000).

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:388.5
XLogP3:0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:388.19982200
Monoisotopic Mass:388.19982200
Topological Polar Surface Area:107
Heavy Atom Count:28
Complexity:589
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ramipril Granules (Intermediate)

Ramipril Tablets
Ingredients	The main ingredient of this product is ramipril.
Indication	The following effects may occur when Ramipril or other ACE inhibitors are used in combination with the following drugs: - Potassium salts, potassium-sparing diuretics (such as spironolactone, amiloride, triamterene): serum potassium concentration increases significantly (serum potassium concentration must be closely monitored when these drugs are used simultaneously). - Antihypertensive drugs (especially diuretics) and other drugs with potential hypotensive effects (such as nitrates, tricyclic antidepressants): the antihypertensive effect of Ramipril is enhanced (during concurrent treatment with diuretics, it is recommended to regularly monitor serum sodium concentration). - Hypnotics, sedatives, anesthetics: blood pressure drops significantly (the anesthesiologist should be informed before surgery that Ramipril treatment is being used). - Sympathomimetic vasopressors (such as epinephrine): the antihypertensive effect of Ramipril may be weakened (close monitoring of blood pressure is recommended). - Allopurinol
Specifications	5mg

Ramipril Tablets
Ingredients	The main ingredient of this product is ramipril.
Indication	The following effects may occur when ramipril tablets or other ACE inhibitors are used in combination with the following drugs: Potassium salts, potassium-sparing diuretics (such as spironolactone, amiloride, triamterene): serum potassium concentration increases significantly (serum potassium concentration must be closely monitored when these drugs are used simultaneously). Antihypertensive drugs (especially diuretics) and other drugs with potential hypotensive effects (such as nitrates, tricyclic antidepressants): the antihypertensive effect of ramipril is enhanced (during concurrent treatment with diuretics, it is recommended to regularly monitor serum sodium concentration). Hypnotics, sedatives, anesthetics: blood pressure drops significantly (the anesthesiologist should be informed before surgery that ramipril is being used for treatment). Sympathomimetic vasopressors (such as epinephrine): the antihypertensive effect of ramipril may be weakened (close monitoring of blood pressure is recommended). Allopurinol, procainamide, cytostatics, immunosuppressants, systemic Cortisol and other drugs that can cause changes in blood picture: increase the possibility of hematological reactions, especially decreased white blood cell count and leukopenia. Lithium: serum lithium concentration increases, thereby enhancing lithium's cardiac and neurotoxicity (serum lithium concentration needs to be monitored regularly). Oral hypoglycemic drugs (such as sulfonylureas, biguanides), insulin: due to the potential reduction of insulin resistance, this product can enhance the effect of hypoglycemic drugs and has the risk of hypoglycemia (especially in the early stages of treatment, blood sugar levels should be carefully monitored). Non-steroidal anti-inflammatory drugs, analgesics (such as indomethacin, acetylsalicylic acid): may weaken the antihypertensive effect of ramipril, and may also increase the risk of renal damage and increased serum potassium concentration. Heparin: may increase serum potassium concentration. Sodium chloride: weakens the antihypertensive effect of ramipril and its effect in relieving heart failure symptoms. Ethanol: enhances the effect of lowering blood pressure and ethanol.
Specifications	5 mg

See More Related Drugs

Registered Holders

APOTEX PHARMACHEM INDIA PVT LTD

United States
Active
UNIMARK REMEDIES LTD

United States
Active
APITORIA PHARMA PRIVATE LTD

United States
Active

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