Chrysin
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Chrysin
structure -
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CAS No:
480-40-0
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Formula:
C15H10O4
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Chemical Name:
Chrysin
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Synonyms:
4H-1-Benzopyran-4-one,5,7-dihydroxy-2-phenyl-;Chrysin;Flavone,5,7-dihydroxy-;5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one;5,7-Dihydroxyflavone;NSC 407436;Crysin;5,7-Dihydroxy-2-phenylchromen-4-one;5,7-Dihydroxy-2-phenyl-4H-chromen-4-one
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CAS No:
Description
Chrysin is one of the most well known estrogen blockers.
Chrysin is a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. It has a role as an anti-inflammatory agent, an antineoplastic agent, an antioxidant, a hepatoprotective agent, an EC 2.7.11.18 (myosin-light-chain kinase) inhibitor and a plant metabolite. It is a dihydroxyflavone and a 7-hydroxyflavonol.
Characteristics
66.8
2.1
Yellow Crystalline Powder
1.4±0.1 g/cm3
285.5 °C
491.9°C at 760 mmHg
192.5±22.2 °C
1.699
84 mg/L @ 25 °C (est)
0-6°C
151.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38
22-24/25-36-26
LK8329050
Xi
Stable. Incompatible with strong oxidizing agents.
Drug Information
Chrysin has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-(5-hydroxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid.
5,7-dihydroxy-flavone
Chrysin Use and Manufacturing
Chrysin is a flavanoid with anti-inflammatory effect and potential protective effects against cancer and cardiovascular disease. Studies show that Chrysin is central benzodiazepine receptor ligand with possible anxiolytic effects. Chrysin was initially believed to have aromatase inhibitor but recent in vivo studies have disproved that.
Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]
Computed Properties
Molecular Weight:254.24
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:254.05790880
Monoisotopic Mass:254.05790880
Topological Polar Surface Area:66.8
Heavy Atom Count:19
Complexity:384
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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