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Narasin

Narasin structure

CAS No:
55134-13-9
Formula:
C43H72O11
Chemical Name:
Narasin
Synonyms:
Salinomycin,4-methyl-,(4S)-;1,6,8-Trioxadispiro[4.1.5.3]pentadecane,salinomycin deriv.;(4S)-4-Methylsalinomycin;Antibiotic A 28086A;A 28086A;Narasin;Antibiotic C 7819B;C 7819B;Narasin A;Narasul;Monteban;124760-07-2;58716-56-6;59979-83-8
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

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Description

White Solid

Narasin is an agent with coccidiostatic and antibacterial properties.

Narasin Basic Attributes

Molecular Weight：

765.03

Exact Mass：

765.03

EC Number：

611-230-1

UNII：

DZY9VU539P

DSSTox ID：

DTXSID2046707

HScode：

2941906000

Characteristics

PSA：

161.21000

XLogP3：

6.59

Density：

1.2±0.1 g/cm3

Melting Point：

98-100 °C

Boiling Point：

842.5±65.0 °C at 760 mmHg

Flash Point：

242.3±27.8 °C

Refractive Index：

1.545

Water Solubility：

methanol: soluble 20mg/mL

Storage Conditions：

2-8°C

Toxicity：

LD50 i.p. in mice: 7.15 mg/kg (Berg)

Specific rotation：

D25 -54° (c = 0.2 in methanol)

Collision Cross Section：

270.1 Å² [M-H]-

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 2811 6.1/PG 2

wgk germany：

hazard class code：

safety instructions：

28-36/37-45

RTECS Number：

VO8640000

Marks：

T+

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

H300

GHS Classification：

|Danger|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. (See all compounds classified as Coccidiostats.)

MeSH Entry Terms：

4-methylsalinomycin

Narasin Use and Manufacturing

Methods of Manufacturing

Produced by fermentation of Streptomyces aureo faciens.

Uses

Narasin is the main component of a polyether antibiotic complex produced by Streptomyces auriofaciens NRRL 5758 & NRRL 8092. Ionophoric antibiotic which inhibits coccidial infection in poultry and mammals. Coccidiostat; growth stimulant.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Veterinary Drug -> ANTIMICROBIAL_AGENT; -> JECFA Functional Classes

Food Additive Classes：

Veterinary Drug -> ANTIMICROBIAL_AGENT;

Computed Properties

Molecular Weight:765.0
XLogP3:6.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:12
Exact Mass:764.50746311
Monoisotopic Mass:764.50746311
Topological Polar Surface Area:161
Heavy Atom Count:54
Complexity:1360
Defined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes