Moxidectin
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Moxidectin
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CAS No:
113507-06-5
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Formula:
C37H53NO8
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Chemical Name:
Moxidectin
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Synonyms:
Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)-;Milbemycin B,5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-,[6R,23E,25S(E)]-;Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)-;Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran],milbemycin B deriv.;(6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)milbemycin B;Moxidectin;CL 301423;Cydectin;Quest;Quest (parasiticide);Vetdectin Oral Drench;ProHeart 6;23-Methoxime-LL-F 28249α;Equest;119719-24-3
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CAS No:
Description
Moxidectin(ProHeart 6; CL301423; Cydectin) is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms.IC50 value:Target: Anti-parasiticMoxidectin is a semisynthetic derivative of nemadectin, which is produced by fermentation by Streptomyces cyano-griseus. Moxidectin treats and controls some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride io
Moxidectin Basic Attributes
639.825
639.82
1308068-626-2
TYC529328W
760424
DTXSID5037577
QP54AB52|P - Antiparasitic products, insecticides and repellents
29322090
Characteristics
116
6
Appearance White or pale yellow, amorphous powder
1.23±0.1 g/cm3(Predicted)
145-154 ºC
790.0±70.0 °C(Predicted)
431.6±35.7 °C
1.581
Insoluble
2-8°C
12.8None
Safety Information
III
6.1(b)
2588
3
25-50
45-61-24/25
PY5438800
T,N
Missing Phrase - N15.00950417
H301-H400
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P301+P310, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P330, P337+P313, P391, P405, and P501|Aggregated GHS information provided by 101 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
For cats with, or at risk from, mixed parasitic infestations by ticks or fleas and ear mites, gastrointestinal nematodes or heartworm. The veterinary medicinal product is exclusively indicated when use against ticks or fleas and one or more of the other target parasites is indicated at the same time.For the treatment of tick and flea infestations in cats providing immediate and persistent flea (Ctenocephalides felis) and tick (Ixodes ricinus) killing activity for 12 weeks. Fleas and ticks must attach to the host and commence feeding in order to be exposed to the active substance.The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).For the treatment of infestations with ear mites (Otodectes cynotis).For the treatment of infections with intestinal roundworm (4th stage larvae, immature adults and adults of Toxocara cati) and hookworm (4th stage larvae, immature adults and adults of Ancylostoma tubaeforme).When administered repeatedly at a 12-week interval, the product continuously prevents heartworm disease caused by Dirofilaria immitis|For dogs with, or at risk from, mixed external and internal parasitic infestations. The veterinary medicinal product is exclusively indicated when use against ticks or fleas and gastrointestinal nematodes is indicated at the same time. The veterinary medicinal product also provides concurrent efficacy for the prevention of heartworm disease and angiostrongylosis.EctoparasitesFor the treatment of tick infestations. The veterinary medicinal product has immediate and persistent tick killing activity for 5 weeks against Ixodes hexagonus, Ixodes ricinus and Rhipicephalus sanguineus and for 4 weeks against Dermacentor reticulatus;For the treatment of flea infestations (Ctenocephalides felis and Ctenocephalides canis). The veterinary medicinal product has immediate and persistent flea killing activity against new infestations for 5 weeks;The veterinary medicinal product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).Gastrointestinal nematodesFor the treatment of gastrointestinal roundworm and hookworm infections:Toxocara canis immature adults (L5) and adults;Ancylostoma caninum L4 larvae, immature adults (L5) and adults;Toxascaris leonina adults;Uncinaria stenocephala adults.Other nematodesFor the prevention of heartworm disease (Dirofilaria immitis);For the prevention of angiostrongylosis by reducing the level of infection with immature adult (L5) stages of Angiostrongylus vasorum.|DogsFor dogs suffering from, or at risk from, mixed parasitic infections:the treatment and prevention of flea infestation (Ctenocephalides felis),the treatment of biting lice (Trichodectes canis),the treatment of ear mite infestation (Otodectes cynotis), sarcoptic mange (caused by Sarcoptes scabiei var. canis), demodicosis (caused by Demodex canis),the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis),the treatment of circulating microfilariae (Dirofilaria immitis),the treatment of cutaneous dirofilariosis (adult stages of Dirofilaria repens)the prevention of cutaneous dirofilariosis (L3 larvae of Dirofilaria repens),the reduction of circulating microfilariae (Dirofilaria repens),the prevention of angiostrongylosis (L4 larvae and immature adults of Angiostrongylus vasorum),the treatment of Angiostrongylus vasorum and Crenosoma vulpis,the prevention of spirocercosis (Spirocerca lupi),the treatment of Eucoleus (syn. Capillaria) boehmi (adults),the treatment of the eye worm Thelazia callipaeda (adults),the treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, adults of Toxascaris leonina and Trichuris vulpis).The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).CatsFor cats suffering from, or at risk from, mixed parasitic infections:the treatment and prevention of flea infestation (Ctenocephalides felis),the treatment of ear mite infestation (Otodectes cynotis),the treatment of notoedric mange (Notoedres cati),the treatment of the lungworm Eucoleus aerophilus (syn. Capillaria aerophila) (adults),the prevention of lungworm disease (L3/L4 larvae of Aelurostrongylus abstrusus),the treatment of the lungworm Aelurostrongylus abstrusus (adults),the treatment of the eye worm Thelazia callipaeda (adults),the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis),the treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara cati and Ancylostoma tubaeforme).The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).FerretsFor ferrets suffering from, or at risk from, mixed parasitic infections:the treatment and prevention of flea infestation (Ctenocephalides felis),the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis).
Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. (See all compounds classified as Anthelmintics.)|Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)|Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)
5-hydroxymilbemycin beta7
Moxidectin Use and Manufacturing
Moxidectin is a semi-synthetic milbemycin derived from nemadectin by selective oxidation followed by methyloximation. Moxidectin was patented in 1991 as an anthelmintic for internal parasite control. The presence of the methyloxime affords moxidectin a greater hydrophobicity and longer biological half-life compared to nemadectin. Moxidectin binds selectively to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
Veterinary drugs -> Bravecto Plus -> EMA Drug Category|Antiparasitic products, insecticides and repellents, Endectocides, Milbemycins -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Simparica Trio -> EMA Drug Category|Antiparasitics -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Advocate -> EMA Drug Category|Antiparasitic products, insecticides and repellents -> Veterinary pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Veterinary Drug -> ANTHELMINTHIC_AGENT;
Computed Properties
Molecular Weight:639.8
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:3
Exact Mass:639.37711765
Monoisotopic Mass:639.37711765
Topological Polar Surface Area:116
Heavy Atom Count:46
Complexity:1340
Defined Atom Stereocenter Count:10
Defined Bond Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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