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Cefpimizole sodium

Cefpimizole sodium structure

CAS No:
85287-61-2
Formula:
C28H26N6O10S2.Na
Chemical Name:
Cefpimizole sodium
Synonyms:
Pyridinium,1-[[(6R,7R)-2-carboxy-7-[[(2R)-[[(5-carboxy-1H-imidazol-4-yl)carbonyl]amino]phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-4-(2-sulfoethyl)-,inner salt,sodium salt (1:1);Pyridinium,1-[[2-carboxy-7-[[[[(5-carboxy-1H-imidazol-4-yl)carbonyl]amino]phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-4-(2-sulfoethyl)-,inner salt,monosodium salt,[6R-[6α,7β(R*)]]-;Pyridinium,1-[[(6R,7R)-2-carboxy-7-[[(2R)-[[(5-carboxy-1H-imidazol-4-yl)carbonyl]amino]phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-4-(2-sulfoethyl)-,inner salt,monosodium salt;AC 1370;Cefpimizole sodium;U 63196E;Ajicef;Renilan
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cefpimizole Sodium is the sodium salt form of cefpimizole, a semisynthetic, broad-spectrum, third-generation cephalosporin with antibacterial activity. Cefpimizole binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Cefpimizole sodium Basic Attributes

Molecular Weight：

692.65

Exact Mass：

692.09700

NCI Thesaurus Code：

C81031

Characteristics

PSA：

279.38000

XLogP3：

-0.14120

Toxicity：

Intravenous-rat LD50: 3500 mg/kg; Intravenous-mouse LD50: 2700 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides, sulfur oxides, sodium oxide fumes

Specific rotation：

D20 -28.2° (c = 0.5 in water)

Safety Information

Storage features：

The warehouse is low-temperature, ventilated and dry

Toxicity

Toxicity class：

practically nontoxic

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

7 beta-D-alpha-(4(5)-carboxyimidazole-5(4)-carboxamido)phenylacetamido-3-(4-beta-sulfoethylpyridinium)methyl-3-cephem-4-carboxylic acid

Cefpimizole sodium Use and Manufacturing

Antibacterial.

Computed Properties

Molecular Weight:692.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:692.09712764
Monoisotopic Mass:692.09712764
Topological Polar Surface Area:279
Heavy Atom Count:47
Complexity:1340
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Cefpimizole sodium

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

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Cefpimizole sodium.

CAS No.: 85287-61-2

Content: 98%

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