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Cefpiramide sodium

Cefpiramide sodium structure

CAS No:
74849-93-7
Formula:
C25H24N8O7S2.Na
Chemical Name:
Cefpiramide sodium
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-2-[[(4-hydroxy-6-methyl-3-pyridinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:1),(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[[[(4-hydroxy-6-methyl-3-pyridinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt,[6R-[6α,7β(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-[[(4-hydroxy-6-methyl-3-pyridinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt,(6R,7R)-;SM 1652;Antibiotic SM 1652;Cefpiramide sodium;Wy 44635;Suncefal;Cefpiran;Sepatren
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cefpiramide sodium (SM-1652; Wy-44635) is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.IC50 value:Target: antibacterial agentCefpiramide was moderately susceptible to hydrolysis by a variety of beta-lactamases from Gram-negative bacilli. cefpiramide was more active against Acinetobacter spp. and Pseudomonas spp. Like most other cephalosporins, cefpiramide inhibited methicillin-susceptible staphylococci, non-enterococcal streptococci, Neisseria go

Cefpiramide sodium is the sodium salt of cefpiramide. It contains a cefpiramide(1-).|Cefpiramide Sodium is the sodium salt form of cefpiramide, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefpiramide binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Cefpiramide sodium Basic Attributes

Molecular Weight：

634.62

Exact Mass：

634.10288173

EC Number：

1592732-453-0

UNII：

137KB7GYKB

NCI Thesaurus Code：

C65304

Characteristics

PSA：

266.19000

XLogP3：

-0.28830

Appearance：

White to slightly yellowish crystalline powder

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

cefpiramide

Cefpiramide sodium Use and Manufacturing

Uses

Antibacterial.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:634.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:9
Exact Mass:634.10288173
Monoisotopic Mass:634.10288173
Topological Polar Surface Area:262
Heavy Atom Count:43
Complexity:1270
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has strong antibacterial activity against Gram-positive bacteria and also has broad-spectrum antibacterial activity against bacteria including Gram-negative bacteria. At the same time, it has strong antibacterial activity against glucose non-fermenting Gram-negative bacteria such as Pseudomonas aeruginosa. The drug has a bactericidal effect and is stable to β-lactamase produced by various bacteria. When used for experimental infection (mice), it shows excellent therapeutic effects. It is sensitive to bacteria resistant to penicillins, other cephalosporins or aminoglycoside antibiotics, especially to Pseudomonas aeruginosa. It has a strong affinity with 1A, 1B and 3 of penicillin binding protein (PBP), inhibiting the synthesis of bacterial cell walls, thereby exerting a bactericidal effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefpiramide Sodium for Injection
Ingredients	The main ingredient of this product is cefpiramide sodium, and its chemical name is: [6R-[6α,7β(R)]]-7-[[[[(4-hydroxy-6-methyl-3-pyridyl)carbonyl]-amino]]-(4-hydroxyphenyl)acetyl]amino-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylate sodium.
Indication	(1) Do not drink alcohol or alcoholic beverages. (2) Taking anticoagulants together may produce synergistic effects and cause bleeding. (3) Precautions for simultaneous use Drug name Clinical symptoms and measures Mechanism, risk factors Diuretics (furanolol, azosemide, piretanide, bumetanide, etc.) It has been reported that when used in combination with other cephalosporin antibiotics, renal dysfunction is aggravated by the mechanism, which is not yet clear. It is considered that the dehydration effect of diuretics causes an increase in blood drug concentration.
Specifications	0.5g (calculated based on 2 pieces of C25H24N8O7)
Manufacturer	Hainan General Sanyang Pharmaceutical Co., Ltd.

Cefpiramide Sodium for Injection
Ingredients	The main ingredient of this product is cefpiramide sodium, and its chemical name is: [6R-[6α,7β(R)]]-7-[[[[(4-hydroxy-6-methyl-3-pyridyl)carbonyl]-amino]]-(4-hydroxyphenyl)acetyl]amino-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylate sodium.
Indication	(1) Do not drink alcohol or alcoholic beverages. (2) Taking anticoagulants together may produce synergistic effects and cause bleeding. (3) Precautions for simultaneous use Drug name Clinical symptoms and measures Mechanism, risk factors Diuretics (furanolol, azosemide, piretanide, bumetanide, etc.) It has been reported that when used in combination with other cephalosporin antibiotics, renal dysfunction is aggravated by the mechanism, which is not yet clear. It is considered that the dehydration effect of diuretics causes an increase in blood drug concentration.
Specifications	2.0g (based on C25H24N8O7S2)
Manufacturer	Hainan Lingkang Pharmaceutical Co., Ltd.

Cefpiramide Sodium for Injection
Ingredients	The main ingredient of this product is cefpiramide sodium, and its chemical name is: [6R-[6α,7β(R)]]-7-[[[[(4-hydroxy-6-methyl-3-pyridyl)carbonyl]-amino]]-(4-hydroxyphenyl)acetyl]amino-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylate sodium.
Indication	(1) Do not drink alcohol or alcoholic beverages. (2) Taking anticoagulants together may produce synergistic effects and cause bleeding. (3) Precautions for simultaneous use Drug name Clinical symptoms and measures Mechanism, risk factors Diuretics (furanolol, azosemide, piretanide, bumetanide, etc.) It has been reported that when used in combination with other cephalosporin antibiotics, renal dysfunction is aggravated by the mechanism, which is not yet clear. It is considered that the dehydration effect of diuretics causes an increase in blood drug concentration.
Specifications	0.5g (calculated as C25H24N807S2)
Manufacturer	CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

See More Related Drugs

Registered Holders

Hainan Huluwa Pharmaceutical Group Co., Ltd.

China
Active
Kaifeng Yugang Pharmaceutical Co., Ltd.

China
Active
Shandong Lukang Pharmaceutical Co., Ltd.

China
Active

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CAS No.: 74849-93-7

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CAS No.: 74849-93-7

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