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R 761

R 761 structure

CAS No:
57184-22-2
Formula:
C45H63N3O12
Chemical Name:
R 761
Synonyms:
3-(4-Isobutylpiperazino)rifamycin;R 761;3-(4-(2-methylpropyl)-1-piperazinyl)-rifamyci;3-(4-isobutyl-1-piperazinyl)rifamycin;3-(4-(2-methylpropyl)-1-piperazinyl)-rifamyci3-(4-isobutyl-1-piperazinyl)rifamycin;3-(4-Isobutyl-1-piperazinyl)-rifamycin SV;Rifamycin, 3-[4-(2-methylpropyl)-1-piperazinyl]-;R 761 USP/EP/BP
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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R 761 Basic Attributes

Molecular Weight：

837.99

Exact Mass：

837.99

Characteristics

PSA：

208

XLogP3：

5.62010

Density：

1.31±0.1 g/cm3(Predicted)

Boiling Point：

913.5±65.0 °C(Predicted)

Flash Point：

546.9ºC

Refractive Index：

1.629

PKA：

3.54±0.70(Predicted)

Drug Information

MeSH Entry Terms：

3-(1-isobutyl-1-piperazinyl)rifamycin SV

Computed Properties

Molecular Weight:838.0
XLogP3:6.7
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:6
Exact Mass:837.44117445
Monoisotopic Mass:837.44117445
Topological Polar Surface Area:208
Heavy Atom Count:60
Complexity:1600
Defined Atom Stereocenter Count:9
Defined Bond Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Rifadin
Ingredients	Molecular weight: c45h63n3o12
Indication	Drinking alcohol daily while taking rifadine can increase the incidence of rifadine hepatotoxicity and increase the metabolism of rifadine. The rifadine dose needs to be adjusted and the patient should be closely monitored for signs of hepatotoxicity.
Manufacturer	Chengdu Jinhua Pharmaceutical Co., Ltd.

Rifadin Tablets
Ingredients	Molecular weight: C45H63N3O12
Indication	1. This product has synergistic effects with ethambutol, ammonia thiourea, isoniazid, streptomycin, p-aminosalicylic acid, tetracycline and sulfonamides without cross-resistance. 2. This product has cross-resistance with rifampicin.
Specifications	50mg