 Home > Encyclopedia > Zorubicin hydrochloride

Zorubicin hydrochloride

Zorubicin hydrochloride structure

CAS No:
36508-71-1
Formula:
C34H35N3O10.ClH
Chemical Name:
Zorubicin hydrochloride
Synonyms:
Benzoic acid,2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide,hydrochloride (1:1);Benzoic acid,[1-[4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide,monohydrochloride,(2S-cis)-;Benzoic acid,[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide,monohydrochloride;Rubidazone hydrochloride;Zorubicin hydrochloride;NSC 164011;RP 22050 hydrochloride
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Request for Quotation

Zorubicin hydrochloride Basic Attributes

Molecular Weight：

682.12

Exact Mass：

681.20900

EC Number：

253-076-4

NSC Number：

164011

DSSTox ID：

DTXSID4023755

Characteristics

PSA：

210.23000

XLogP3：

4.13900

Density：

1.54g/cm3

Refractive Index：

1.705

Toxicity：

LD50 in mice (mg/kg): 13.66 s.c., 4.42 i.p., 8.50 i.v. (Maral, 1972)

Specific rotation：

D20 -50° (c = 0.2 in water)

Safety Information

Transport codes：

UN2811 6.1/PG 2

Drug Information

MeSH：

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

MeSH Entry Terms：

daunomycin benzoylhydrazone

Zorubicin hydrochloride Use and Manufacturing

Methods of Manufacturing

Compound (I) and benzoyl hydrazide are reacted in ethanol containing acetic acid at 60°C or 65°C, and then acidified with hydrochloric acid to obtain zorubicin hydrochloride.

Uses

It is a semi-synthetic anti-tumor antibiotic similar to doxycycline, with similar efficacy to doxorubicin. For the relief of acute lymphocytic leukemia and acute blasts, especially acute monocytic leukemia.

Computed Properties

Molecular Weight:682.1
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:6
Exact Mass:681.2089220
Monoisotopic Mass:681.2089220
Topological Polar Surface Area:210
Heavy Atom Count:48
Complexity:1230
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:4
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes