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Tobramycin sulphate

Tobramycin sulphate structure

CAS No:
49842-07-1
Formula:
C18H39N5O13S
Chemical Name:
Tobramycin sulphate
Synonyms:
TOBRAMYCIN SULFATE SALT;1-epitobramycinsulfate;d-6-trideoxy-alpha-d-ribohexopyranosyl-(1-4))-2-deoxysulfate(salt);obracine;streptamine,o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-6)-o-(2,6-diamino-2,3,;tenemicin;O-[3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine sulfate;TobraMycin Sulfate API
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Tobramycin sulfate (Nebramycin Factor 6 sulfate) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms[1].

Tobramycin sulphate Basic Attributes

Molecular Weight：

565.59

Exact Mass：

565.226501

EC Number：

256-499-2

Color/Form：

White to off-white

HScode：

2941900000

Characteristics

PSA：

351.15000

XLogP3：

-2.36630

Density：

1.52g/cm3

Boiling Point：

775.4ºC at 760mmHg

Flash Point：

422.8ºC

Water Solubility：

Soluble in water (50 mg/ml).

Storage Conditions：

2-8°C

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

hazard class code：

safety instructions：

53-22-36/37/39-45

Marks：

Hazard Statements：

61-20/21/22

GHS Classification：

|Danger|H312 (98.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]|P201, P202, P261, P271, P280, P281, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P363, P405, and P501|Aggregated GHS information provided by 91 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301 (16.67%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Tobramycin sulphate Use and Manufacturing

Nebcin (Lilly).

Tobramycin sulfate is used as an antibiotic which is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections1. Product T1783 has been used to study antibiotic resistance2.

Computed Properties

Molecular Weight:565.6
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:6
Exact Mass:565.22650749
Monoisotopic Mass:565.22650749
Topological Polar Surface Area:351
Heavy Atom Count:37
Complexity:691
Undefined Atom Stereocenter Count:14
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Tobramycin sulphate

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Tobramycin sulfate

CAS No.: 49842-07-1

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Tobramycin sulfate

CAS No.: 49842-07-1

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