CLINDAMYCIN HYDROCHLORIDE
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CLINDAMYCIN HYDROCHLORIDE
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CAS No:
58207-19-5
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Formula:
C18H34Cl2N2O5S
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Chemical Name:
CLINDAMYCIN HYDROCHLORIDE
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Synonyms:
U-21251F;(7S)-7-CHLORO-7-DEOXYLINCOMYCIN HYDROCHLORIDE;7(S)-CHLORO-7-DEOXYLINCOMYCIN;7(S)-CHLORO-7-DEOXYLINCOMYCIN HCL;7[S]-CHLORO-7-DEOXYLINCOMYCIN HYDROCHLORIDE;(2S-TRANS)-METHYL 7-CHLORO-6,7,8-TRIDEOXY-6[[(1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL]AMINO]-1-THIO-L-THREO-ALPHA-D-GALACTO-OCTOPYRANOSIDE;CLEOCIN;CLEOCIN HYDROCHLORIDE
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CAS No:
Description
Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-
Characteristics
136.79000
1.45600
White Crystalline Solid
143 °C
647ºC at 760 mmHg
345.1ºC
143 ° (C=2, H2O)
soluble in water
Drug Function and Efficacy
Clindamycin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the ribosome. It is bacteriostatic and active against various Gram-positive bacteria and anaerobic bacteria.
Registered Holders
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Zhejiang Hisoar Chuannan Pharmaceutical Co.,Ltd.
Active
Japan
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SUZHOU NUMBER 4 PHARMACEUTICAL FACTORY
Inactive
United States
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