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Clindamycin hydrochloride monohydrate

Clindamycin hydrochloride monohydrate structure

CAS No:
58207-19-5
Formula:
C18H34Cl2N2O5S
Chemical Name:
Clindamycin hydrochloride monohydrate
Synonyms:
U-21251F;(7S)-7-CHLORO-7-DEOXYLINCOMYCIN HYDROCHLORIDE;7(S)-CHLORO-7-DEOXYLINCOMYCIN;7(S)-CHLORO-7-DEOXYLINCOMYCIN HCL;7[S]-CHLORO-7-DEOXYLINCOMYCIN HYDROCHLORIDE;(2S-TRANS)-METHYL 7-CHLORO-6,7,8-TRIDEOXY-6[[(1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL]AMINO]-1-THIO-L-THREO-ALPHA-D-GALACTO-OCTOPYRANOSIDE;(2S-trans)-Methyl 7-Chloro-6,7,8-trideoxy-6[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside;Clindamycin Hydrochloride Monohydrate
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-

White Crystalline Solid

Clindamycin hydrochloride monohydrate Basic Attributes

Molecular Weight：

461.44

Exact Mass：

478.167114

EC Number：

244-398-6

Color/Form：

White to Almost white

HScode：

29419090

Characteristics

PSA：

136.79000

XLogP3：

1.45600

Appearance：

White Crystalline Solid

Melting Point：

143 °C

Boiling Point：

647ºC at 760 mmHg

Flash Point：

345.1ºC

Refractive Index：

143 ° (C=2, H2O)

Water Solubility：

Soluble in water

Critical Temperature & Pressure：

2-8°C

Safety Information

Hazard category：

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

26-37/39-24/25

RTECS Number：

GF2275000

Marks：

Hazard Statements：

36/37/38

Clindamycin hydrochloride monohydrate Use and Manufacturing

An antibiotic

Clindamycin hydrochloride monohydrate is an antibacterial agent that is a semisynthetic analog of lincomycin.

Drug Function and Efficacy

Clindamycin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the ribosome. It is bacteriostatic and active against various Gram-positive bacteria and anaerobic bacteria.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

CLINDAMYCIN HYDROCHLORIDE- clindamycin hydrochloride_capsule
Indication	Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.
Manufacturer	Proficient Rx LP

Registered Holders

Zhejiang Hisoar Chuannan Pharmaceutical Co.,Ltd.

Japan
Active
SUZHOU NUMBER 4 PHARMACEUTICAL FACTORY

United States
Inactive

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Clindamycin hydrochloride monohydrate

CAS No.: 58207-19-5

Content: 99.00%

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Guide of Clindamycin hydrochloride monohydrate

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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Clindamycin hydrochloride monohydrate

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