 Home > Encyclopedia > Docetaxel

Docetaxel

Docetaxel structure

CAS No:
125354-16-7
Formula:
C45H55NO15
Chemical Name:
Docetaxel
Synonyms:
10-Acetyldocetaxel;10-Acetyltaxotere;Docetaxal;PNU 101383;ACETYLDOCETAXEL, 10-(P);DocetaxelN-Debenzoyl-N-(tert-butoxycarbonyl)taxol;DOCETAXOL;Docetaxel
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Docetaxel is available in single-dose vials of 20 mg/0.5 mLand 80 mg/2 mL for IV administration in the treatment of breast, NSCLC, and prostate cancers. It has also been utilizedin non–FDA-approved treatment of head, neck, gastric,bladder, and refractory ovarian cancers. Docetaxel is highly plasma protein bound (80%) andwidely distributed with the highest concentration in the hepatobiliarysystem, but it does not appear to cross the bloodbrainbarrier.

Docetaxel Basic Attributes

Molecular Weight：

849.922

Exact Mass：

849.357178

EC Number：

1533716-785-6

HScode：

2932999099

Characteristics

PSA：

231

XLogP3：

7.19

Density：

1.36±0.1 g/cm3(Predicted)

Melting Point：

201-203 °C(Solv: methanol (67-56-1))

Boiling Point：

901.4±65.0 °C(Predicted)

Flash Point：

499.0±34.3 °C

Refractive Index：

1.606

Vapor Pressure：

5.54E-35mmHg at 25°C

Docetaxel Use and Manufacturing

Docetaxal is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.

Computed Properties

Molecular Weight:849.9
XLogP3:2.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:15
Exact Mass:849.35717005
Monoisotopic Mass:849.35717005
Topological Polar Surface Area:231
Heavy Atom Count:61
Complexity:1770
Defined Atom Stereocenter Count:11
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Docetaxel

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Docetaxel

CAS No.: 125354-16-7

Content: 99.00%

Inquiry
Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

Docetaxal API 99% white powder

CAS No.: 125354-16-7

Content: 99%

Inquiry
Honour Enterprise Company Limited Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Semaglutide,Tirzepatide,API,Enzyme

More than 15 years GMP Factory Suppy 99.5% Docetaxel Medical Grade CAS125354-16-7

CAS No.: 125354-16-7

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry