Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?)
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![Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?) structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/c53f2940ed3d4258953594ac990961ce.png "Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?)")
Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?)
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CAS No:
55658-47-4
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Formula:
C57H89N19O21S2.xClH
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Chemical Name:
Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?)
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Synonyms:
Bleomycinamide,N1-[3-[(4-aminobutyl)amino]propyl]-,hydrochloride (1:?);Bleomycinamide,N1-[3-[(4-aminobutyl)amino]propyl]-,hydrochloride;Bleomycin A5 hydrochloride;70502-64-6
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CAS No:
Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?) Basic Attributes
1477.04
1475.57000
Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?) Use and Manufacturing
Bleomycin A5 Hydrochloride is used as an anti-cancer drug used to combat various forms of carcinoma via activated-apoptosis of cancer cells.
Computed Properties
Molecular Weight:1477.0
Hydrogen Bond Donor Count:23
Hydrogen Bond Acceptor Count:33
Rotatable Bond Count:40
Exact Mass:1475.5688610
Monoisotopic Mass:1475.5688610
Topological Polar Surface Area:722
Heavy Atom Count:100
Complexity:2620
Undefined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Pingyangmycin is a bleomycin antitumor antibiotic produced by Streptomyces pingyangensis. It can inhibit the synthesis of cancer cell DNA and cut off DNA chains, affect the metabolic function of cancer cells, and promote cancer cell degeneration and necrosis. In vitro experiments have shown that it has a strong killing effect on a variety of cancer cells such as liver cancer BEL7402, gastric cancer MGC803, nasopharyngeal cancer CNB-2, colon cancer HT-29 and oral squamous cell carcinoma KB. In vivo, it has a significant inhibitory effect on subcutaneously inoculated rats of Wacker's tumor 256, mouse sarcoma 180, sarcoma 37, liver cancer and melanoma, and its anti-tumor effect is stronger than mitomycin and BleomycinA2. It is a non-specific drug for the cell cycle and has no significant effect on the body's immune function and hematopoietic function.
Registered Holders
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Zhejiang Hisun Pharmaceutical Co., Ltd.
Active
China
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Jilin Aodong Pharmaceutical Industry Group Yanji Co., Ltd.
Active
China
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Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?)
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