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N-(2-Chloroethyl)-N′-(2-hydroxyethyl)-N-nitrosourea

N-(2-Chloroethyl)-N′-(2-hydroxyethyl)-N-nitrosourea structure

CAS No:
60784-46-5
Formula:
C5H10ClN3O3
Chemical Name:
N-(2-Chloroethyl)-N′-(2-hydroxyethyl)-N-nitrosourea
Synonyms:
Urea,N-(2-chloroethyl)-N′-(2-hydroxyethyl)-N-nitroso-;N-(2-Chloroethyl)-N′-(2-hydroxyethyl)-N-nitrosourea;1-(2-Hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea;NSC 294895;1-(2-Chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea;HECNU;1-Nitroso-1-(2-chloroethyl)-3-(2-hydroxyethyl)urea;Elmustine;Hemustine
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

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Description

Elmustine is a (2-chloroethy1)nitrosourea derivative related to carmustine, with antineoplastic activity.

N-(2-Chloroethyl)-N′-(2-hydroxyethyl)-N-nitrosourea Basic Attributes

Molecular Weight：

195.605

Exact Mass：

195.60

EC Number：

262-429-1

UNII：

NAT2FD82D7

NSC Number：

294895

DSSTox ID：

DTXSID80209610

NCI Thesaurus Code：

C73262

Characteristics

PSA：

XLogP3：

0.30140

Density：

1.45g/cm3

Melting Point：

56 °C

Refractive Index：

1.549

Toxicity：

Peritoneal-rat LD50: 25.3 mg/kg; peritoneal-mouse LD50: 25 mg/kg

Flammability characteristics：

Flammable; Fire site releases toxic chloride, nitrogen oxide fumes

Safety Information

Storage features：

The warehouse is low-temperature, ventilated and dry; stored separately from food materials

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)

MeSH Entry Terms：

1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea

Computed Properties

Molecular Weight:195.60
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:195.0410689
Monoisotopic Mass:195.0410689
Topological Polar Surface Area:82
Heavy Atom Count:12
Complexity:155
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of N-(2-Chloroethyl)-N′-(2-hydroxyethyl)-N-nitrosourea

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Computed Properties
Latest News
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N-(2-Chloroethyl)-N′-(2-hydroxyethyl)-N-nitrosourea

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